*AIK Fotboll 2-2 Shkendija'79
| 11.08.2022 | Shkendija'79 | 1-1/p.2-3 | AIK Fotboll | |
| 04.08.2022 | AIK Fotboll | 1-1 | Shkendija'79 | |
Paide Linnameeskond 0-5 Anderlecht *
| 11.08.2022 | Anderlecht | 3-0 | Paide Linnameeskond | |
| 04.08.2022 | Paide Linnameeskond | 0-2 | Anderlecht | |
*Maccabi Tel Aviv 3-2 Aris Salonica
| 11.08.2022 | Aris Salonica | 2-1 | Maccabi Tel Aviv | |
| 04.08.2022 | Maccabi Tel Aviv | 2-0 | Aris Salonica | |
Dundee United 1-7 AZ Alkmaar *
| 11.08.2022 | AZ Alkmaar | 7-0 | Dundee United | |
| 04.08.2022 | Dundee United | 1-0 | AZ Alkmaar | |
*Viborg FF 5-1 B36 Torshavn
| 09.08.2022 | B36 Torshavn | 1-2 | Viborg FF | |
| 03.08.2022 | Viborg FF | 3-0 | B36 Torshavn | |
Breidablik 1-6 Istanbul Basaksehir *
| 11.08.2022 | Istanbul Basaksehir | 3-0 | Breidablik | |
| 04.08.2022 | Breidablik | 1-3 | Istanbul Basaksehir | |
KuPS Kuopio 0-5 BSC Young Boys *
| 11.08.2022 | BSC Young Boys | 3-0 | KuPS Kuopio | |
| 04.08.2022 | KuPS Kuopio | 0-2 | BSC Young Boys | |
Sepsi OSK 2-6 Djurgårdens IF *
| 11.08.2022 | Djurgårdens IF | 3-1 | Sepsi OSK | |
| 04.08.2022 | Sepsi OSK | 1-3 | Djurgårdens IF | |
Dunajska Streda 0-2 FCSB *
| 11.08.2022 | FCSB | 1-0 | Dunajska Streda | |
| 03.08.2022 | Dunajska Streda | 0-1 | FCSB | |
Brøndby IF 2-2 FC Basel *
| 11.08.2022 | FC Basel | 2-1/p.3-1 | Brøndby IF | |
| 04.08.2022 | Brøndby IF | 1-0 | FC Basel | |
Cukaricki Belgrade 2-7 FC Twente *
| 11.08.2022 | FC Twente | 4-1 | Cukaricki Belgrade | |
| 04.08.2022 | Cukaricki Belgrade | 1-3 | FC Twente | |
*APOEL FC 1-0 FK Kyzylzhar
| 11.08.2022 | FK Kyzylzhar | 0-0 | APOEL FC | |
| 04.08.2022 | APOEL FC | 1-0 | FK Kyzylzhar | |
*Hajduk Split 3-2 Vitória Guimarães
| 10.08.2022 | Vitória Guimarães | 1-0 | Hajduk Split | |
| 04.08.2022 | Hajduk Split | 3-1 | Vitória Guimarães | |
FC Lugano 1-5 Hapoel Be'er Sheva *
| 11.08.2022 | Hapoel Be'er Sheva | 3-1 | FC Lugano | |
| 04.08.2022 | FC Lugano | 0-2 | Hapoel Be'er Sheva | |
*Molde FK 4-2 Kisvárda FC
| 11.08.2022 | Kisvárda FC | 2-1 | Molde FK | |
| 04.08.2022 | Molde FK | 3-0 | Kisvárda FC | |
*Hamrun Spartans 2-2 Levski Sofia
| 11.08.2022 | Levski Sofia | 1-2/p.1-4 | Hamrun Spartans | |
| 04.08.2022 | Hamrun Spartans | 0-1 | Levski Sofia | |
Lillestrom SK 1-5 Royal Antwerp *
| 11.08.2022 | Royal Antwerp | 2-0 | Lillestrom SK | |
| 04.08.2022 | Lillestrom SK | 1-3 | Royal Antwerp | |
*Fehervar FC 7-1 Petrocub Hîncești
| 11.08.2022 | Petrocub Hîncești | 1-2 | Fehervar FC | |
| 04.08.2022 | Fehervar FC | 5-0 | Petrocub Hîncești | |
Spartak Trnava 0-3 Raków *
| 11.08.2022 | Raków | 1-0 | Spartak Trnava | |
| 04.08.2022 | Spartak Trnava | 0-2 | Raków | |
Neftchi Baku 2-3 Rapid Wien *
| 11.08.2022 | Rapid Wien | 2-0 AET | Neftchi Baku | |
| 04.08.2022 | Neftchi Baku | 2-1 | Rapid Wien | |
Riga FC 1-5 Gil Vicente *
| 11.08.2022 | Gil Vicente | 4-0 | Riga FC | |
| 03.08.2022 | Riga FC | 1-1 | Gil Vicente | |
*Slavia Praha 3-1 Panathinaikos
| 11.08.2022 | Panathinaikos | 1-1 | Slavia Praha | |
| 04.08.2022 | Slavia Praha | 2-0 | Panathinaikos | |
*CSKA Sofia 2-1 St Patrick's Dublin
| 11.08.2022 | St Patrick's Dublin | 0-2 | CSKA Sofia | |
| 04.08.2022 | CSKA Sofia | 0-1 | St Patrick's Dublin | |
*Viking FK 5-2 Sligo Rovers
| 11.08.2022 | Sligo Rovers | 1-0 | Viking FK | |
| 04.08.2022 | Viking FK | 5-1 | Sligo Rovers | |
*Wolfsberger AC 4-0 Gzira United
| 09.08.2022 | Gzira United | 0-4 | Wolfsberger AC | |
| 03.08.2022 | Wolfsberger AC | 0-0 | Gzira United | |
Zorya Luhansk 1-3 Universitatea Craiova *
| 11.08.2022 | Universitatea Craiova | 3-0 | Zorya Luhansk | |
| 04.08.2022 | Zorya Luhansk | 1-0 | Universitatea Craiova | |