Lazio 2-4 AZ Alkmaar *
| 16.03.2023 | AZ Alkmaar | 2-1 | Lazio | |
| 07.03.2023 | Lazio | 1-2 | AZ Alkmaar | |
*Lech Poznan 5-0 Djurgårdens IF
| 16.03.2023 | Djurgårdens IF | 0-3 | Lech Poznan | |
| 09.03.2023 | Lech Poznan | 2-0 | Djurgårdens IF | |
*FC Basel 4-4 Slovan Bratislava
| 16.03.2023 | Slovan Bratislava | 2-2/p.1-4 | FC Basel | |
| 09.03.2023 | FC Basel | 2-2 | Slovan Bratislava | |
*Fiorentina 5-1 Sivasspor
| 16.03.2023 | Sivasspor | 1-4 | Fiorentina | |
| 09.03.2023 | Fiorentina | 1-0 | Sivasspor | |
*KAA Gent 5-2 Istanbul Basaksehir
| 15.03.2023 | Istanbul Basaksehir | 1-4 | KAA Gent | |
| 09.03.2023 | KAA Gent | 1-1 | Istanbul Basaksehir | |
Sheriff Tiraspol 1-4 OGC Nice *
| 16.03.2023 | OGC Nice | 3-1 | Sheriff Tiraspol | |
| 09.03.2023 | Sheriff Tiraspol | 0-1 | OGC Nice | |
*Anderlecht 2-1 Villarreal CF
| 16.03.2023 | Villarreal CF | 0-1 | Anderlecht | |
| 09.03.2023 | Anderlecht | 1-1 | Villarreal CF | |
AEK Larnaca 0-6 West Ham *
| 16.03.2023 | West Ham | 4-0 | AEK Larnaca | |
| 09.03.2023 | AEK Larnaca | 0-2 | West Ham | |