*FC København 4-3 1. FC Heidenheim
| 20.02.2025 | 1. FC Heidenheim | 1-3 AET | FC København | |
| 13.02.2025 | FC København | 1-2 | 1. FC Heidenheim | |
*Borac Banja Luka 1-0 Olimpija Ljubljana
| 20.02.2025 | Olimpija Ljubljana | 0-0 | Borac Banja Luka | |
| 13.02.2025 | Borac Banja Luka | 1-0 | Olimpija Ljubljana | |
FK TSC Bačka Topola 2-6 Jagiellonia *
| 20.02.2025 | Jagiellonia | 3-1 | FK TSC Bačka Topola | |
| 13.02.2025 | FK TSC Bačka Topola | 1-3 | Jagiellonia | |
KAA Gent 1-3 Real Betis *
| 20.02.2025 | Real Betis | 0-1 | KAA Gent | |
| 13.02.2025 | KAA Gent | 0-3 | Real Betis | |
*Molde FK 1-1 Shamrock Rovers
| 20.02.2025 | Shamrock Rovers | 0-1/p.4-5 | Molde FK | |
| 13.02.2025 | Molde FK | 0-1 | Shamrock Rovers | |
Omonia Nicosia 2-3 Pafos FC *
| 20.02.2025 | Pafos FC | 2-1 | Omonia Nicosia | |
| 13.02.2025 | Omonia Nicosia | 1-1 | Pafos FC | |
Vikingur Reykjavik 2-3 Panathinaikos *
| 20.02.2025 | Panathinaikos | 2-0 | Vikingur Reykjavik | |
| 13.02.2025 | Vikingur Reykjavik | 2-1 | Panathinaikos | |