Anderlecht 0-5 AFC Ajax *
| 24.02.2011 | AFC Ajax | 2-0 | Anderlecht | |
| 17.02.2011 | Anderlecht | 0-3 | AFC Ajax | |
Aris Salonica 0-3 Manchester City *
| 24.02.2011 | Manchester City | 3-0 | Aris Salonica | |
| 15.02.2011 | Aris Salonica | 0-0 | Manchester City | |
BATE Borisov 2-2 Paris St. Germain *
| 24.02.2011 | Paris St. Germain | 0-0 | BATE Borisov | |
| 17.02.2011 | BATE Borisov | 2-2 | Paris St. Germain | |
Besiktas JK 1-8 Dynamo Kyiv *
| 24.02.2011 | Dynamo Kyiv | 4-0 | Besiktas JK | |
| 17.02.2011 | Besiktas JK | 1-4 | Dynamo Kyiv | |
PAOK Salonica 1-2 CSKA Moscow *
| 22.02.2011 | CSKA Moscow | 1-1 | PAOK Salonica | |
| 17.02.2011 | PAOK Salonica | 0-1 | CSKA Moscow | |
FC Basel 3-4 Spartak Moscow *
| 24.02.2011 | Spartak Moscow | 1-1 | FC Basel | |
| 17.02.2011 | FC Basel | 2-3 | Spartak Moscow | |
Lech Poznan 1-2 SC Braga *
| 24.02.2011 | SC Braga | 2-0 | Lech Poznan | |
| 17.02.2011 | Lech Poznan | 1-0 | SC Braga | |
Sparta Praha 0-1 Liverpool *
| 24.02.2011 | Liverpool | 1-0 | Sparta Praha | |
| 17.02.2011 | Sparta Praha | 0-0 | Liverpool | |
Metalist Kharkiv 0-6 Bayer Leverkusen *
| 24.02.2011 | Bayer Leverkusen | 2-0 | Metalist Kharkiv | |
| 17.02.2011 | Metalist Kharkiv | 0-4 | Bayer Leverkusen | |
Lille OSC 3-5 PSV Eindhoven *
| 24.02.2011 | PSV Eindhoven | 3-1 | Lille OSC | |
| 17.02.2011 | Lille OSC | 2-2 | PSV Eindhoven | |
*Rangers FC 3-3 Sporting Lisboa
| 24.02.2011 | Sporting Lisboa | 2-2 | Rangers FC | |
| 17.02.2011 | Rangers FC | 1-1 | Sporting Lisboa | |
Rubin Kazan 2-4 FC Twente *
| 24.02.2011 | FC Twente | 2-2 | Rubin Kazan | |
| 17.02.2011 | Rubin Kazan | 0-2 | FC Twente | |
Sevilla FC 2-2 FC Porto *
| 23.02.2011 | FC Porto | 0-1 | Sevilla FC | |
| 17.02.2011 | Sevilla FC | 1-2 | FC Porto | |
SSC Napoli 1-2 Villarreal CF *
| 24.02.2011 | Villarreal CF | 2-1 | SSC Napoli | |
| 17.02.2011 | SSC Napoli | 0-0 | Villarreal CF | |
*SL Benfica 4-1 VfB Stuttgart
| 24.02.2011 | VfB Stuttgart | 0-2 | SL Benfica | |
| 17.02.2011 | SL Benfica | 2-1 | VfB Stuttgart | |
BSC Young Boys 3-4 Zenit *
| 24.02.2011 | Zenit | 3-1 | BSC Young Boys | |
| 17.02.2011 | BSC Young Boys | 2-1 | Zenit | |