*Anorthosis FC 4-0 Banants Yerevan
| 08.07.2010 | Banants Yerevan | 0-1 | Anorthosis FC | |
| 01.07.2010 | Anorthosis FC | 3-0 | Banants Yerevan | |
Ulisses Yerevan 0-1 Bnei Yehuda *
| 08.07.2010 | Bnei Yehuda | 1-0 | Ulisses Yerevan | |
| 01.07.2010 | Ulisses Yerevan | 0-0 | Bnei Yehuda | |
*Dinamo Tbilisi 2-1 Flora Tallinn
| 08.07.2010 | Flora Tallinn | 0-0 | Dinamo Tbilisi | |
| 01.07.2010 | Dinamo Tbilisi | 2-1 | Flora Tallinn | |
KF Laci 2-8 Dnepr Mogilev *
| 08.07.2010 | Dnepr Mogilev | 7-1 | KF Laci | |
| 01.07.2010 | KF Laci | 1-1 | Dnepr Mogilev | |
CS Grevenmacher 4-5 Dundalk FC *
| 08.07.2010 | Dundalk FC | 2-1 | CS Grevenmacher | |
| 01.07.2010 | CS Grevenmacher | 3-3 | Dundalk FC | |
*Rabotnicki Skopje 11-0 FC Lusitanos (AND)
| 08.07.2010 | FC Lusitanos (AND) | 0-6 | Rabotnicki Skopje | |
| 01.07.2010 | Rabotnicki Skopje | 5-0 | FC Lusitanos (AND) | |
FC Nitra 3-5 Gyori ETO FC *
| 08.07.2010 | Gyori ETO FC | 3-1 | FC Nitra | |
| 01.07.2010 | FC Nitra | 2-2 | Gyori ETO FC | |
Llanelli Town 4-5 FK Tauras *
| 08.07.2010 | FK Tauras | 3-2 AET | Llanelli Town | |
| 01.07.2010 | Llanelli Town | 2-2 | FK Tauras | |
FK Zeta 1-1 Dacia Chisinau *
| 08.07.2010 | Dacia Chisinau | 0-0 | FK Zeta | |
| 01.07.2010 | FK Zeta | 1-1 | Dacia Chisinau | |
NSI Runavik 1-4 Gefle IF *
| 08.07.2010 | Gefle IF | 2-1 | NSI Runavik | |
| 01.07.2010 | NSI Runavik | 0-2 | Gefle IF | |
*Kalmar FF 4-0 EB/Streymur
| 08.07.2010 | EB/Streymur | 0-3 | Kalmar FF | |
| 01.07.2010 | Kalmar FF | 1-0 | EB/Streymur | |
*Olimpia Balti 1-1 Khazar Lankaran
| 08.07.2010 | Khazar Lankaran | 1-1 | Olimpia Balti | |
| 01.07.2010 | Olimpia Balti | 0-0 | Khazar Lankaran | |
*KR Reykjavik 5-2 Glentoran Belfast
| 08.07.2010 | Glentoran Belfast | 2-2 | KR Reykjavik | |
| 01.07.2010 | KR Reykjavik | 3-0 | Glentoran Belfast | |
*Qarabag FK 5-2 Metalurg Skopje
| 08.07.2010 | Metalurg Skopje | 1-1 | Qarabag FK | |
| 01.07.2010 | Qarabag FK | 4-1 | Metalurg Skopje | |
Olimpija Ljubljana 0-5 Siroki Brijeg *
| 08.07.2010 | Siroki Brijeg | 3-0 | Olimpija Ljubljana | |
| 01.07.2010 | Olimpija Ljubljana | 0-2 | Siroki Brijeg | |
*TPS Turku 7-1 Port Talbot
| 08.07.2010 | Port Talbot | 0-4 | TPS Turku | |
| 01.07.2010 | TPS Turku | 3-1 | Port Talbot | |
*Randers FC 7-3 F91 Dudelange
| 08.07.2010 | F91 Dudelange | 2-1 | Randers FC | |
| 01.07.2010 | Randers FC | 6-1 | F91 Dudelange | |
Shakhtyor Karagandy 1-3 Ruch Chorzow *
| 08.07.2010 | Ruch Chorzow | 1-0 | Shakhtyor Karagandy | |
| 01.07.2010 | Shakhtyor Karagandy | 1-2 | Ruch Chorzow | |
*FC Zestafoni 5-0 SC Faetano
| 08.07.2010 | SC Faetano | 0-0 | FC Zestafoni | |
| 01.07.2010 | FC Zestafoni | 5-0 | SC Faetano | |
*Portadown FC 2-1 Skonto Riga
| 08.07.2010 | Skonto Riga | 0-1 | Portadown FC | |
| 01.07.2010 | Portadown FC | 1-1 | Skonto Riga | |
*Šibenik 3-0 Sliema Wanderers
| 08.07.2010 | Sliema Wanderers | 0-3 | Šibenik | |
| 01.07.2010 | Šibenik | 0-0 | Sliema Wanderers | |
*Torpedo Zhodino 6-1 Fylkir FC
| 08.07.2010 | Fylkir FC | 1-3 | Torpedo Zhodino | |
| 01.07.2010 | Torpedo Zhodino | 3-0 | Fylkir FC | |
Trans Narva 0-7 MyPa *
| 08.07.2010 | MyPa | 5-0 | Trans Narva | |
| 01.07.2010 | Trans Narva | 0-2 | MyPa | |
UE Santa Coloma 0-5 FK Mogren *
| 08.07.2010 | FK Mogren | 2-0 | UE Santa Coloma | |
| 01.07.2010 | UE Santa Coloma | 0-3 | FK Mogren | |
*KF Tirana 1-0 Zalaegerszegi TE
| 08.07.2010 | Zalaegerszegi TE | 0-1 AET | KF Tirana | |
| 01.07.2010 | KF Tirana | 0-0 | Zalaegerszegi TE | |
Tobol Kostanay 2-4 Zrinjski Mostar *
| 08.07.2010 | Zrinjski Mostar | 2-1 | Tobol Kostanay | |
| 01.07.2010 | Tobol Kostanay | 1-2 | Zrinjski Mostar | |