*Austria Wien 3-2 Siroki Brijeg
| 22.07.2010 | Siroki Brijeg | 0-1 | Austria Wien | |
| 15.07.2010 | Austria Wien | 2-2 | Siroki Brijeg | |
*Besiktas JK 7-0 Vikingur Gota
| 22.07.2010 | Vikingur Gota | 0-4 | Besiktas JK | |
| 15.07.2010 | Besiktas JK | 3-0 | Vikingur Gota | |
*Cliftonville Belfast 1-0 Cibalia Vinkovci
| 22.07.2010 | Cibalia Vinkovci | 0-0 | Cliftonville Belfast | |
| 15.07.2010 | Cliftonville Belfast | 1-0 | Cibalia Vinkovci | |
Differdange 3-5 Spartak Zlatibor Voda *
| 22.07.2010 | Spartak Zlatibor Voda | 2-0 | Differdange | |
| 15.07.2010 | Differdange | 3-3 | Spartak Zlatibor Voda | |
Olimpia Balti 1-7 Dinamo Bucuresti *
| 22.07.2010 | Dinamo Bucuresti | 5-1 | Olimpia Balti | |
| 15.07.2010 | Olimpia Balti | 0-2 | Dinamo Bucuresti | |
*Dinamo Minsk 10-1 JK Sillamae Kalev
| 22.07.2010 | JK Sillamae Kalev | 0-5 | Dinamo Minsk | |
| 15.07.2010 | Dinamo Minsk | 5-1 | JK Sillamae Kalev | |
Gefle IF 2-4 Dinamo Tbilisi *
| 22.07.2010 | Dinamo Tbilisi | 2-1 | Gefle IF | |
| 15.07.2010 | Gefle IF | 1-2 | Dinamo Tbilisi | |
Stabaek 3-3 Dnepr Mogilev *
| 22.07.2010 | Dnepr Mogilev | 1-1 | Stabaek | |
| 15.07.2010 | Stabaek | 2-2 | Dnepr Mogilev | |
FC Honka Espoo 2-3 Bangor City *
| 22.07.2010 | Bangor City | 2-1 | FC Honka Espoo | |
| 15.07.2010 | FC Honka Espoo | 1-1 | Bangor City | |
*Brøndby IF 3-0 FC Vaduz
| 22.07.2010 | FC Vaduz | 0-0 | Brøndby IF | |
| 15.07.2010 | Brøndby IF | 3-0 | FC Vaduz | |
*FC Zestafoni 3-1 Dukla Banska Bystrica
| 22.07.2010 | Dukla Banska Bystrica | 1-0 | FC Zestafoni | |
| 15.07.2010 | FC Zestafoni | 3-0 | Dukla Banska Bystrica | |
FK Baku 2-4 FK Buducnost *
| 22.07.2010 | FK Buducnost | 1-2 | FK Baku | |
| 15.07.2010 | FK Baku | 0-3 | FK Buducnost | |
FK Ventspils 1-3 Teteks Tetovo *
| 22.07.2010 | Teteks Tetovo | 3-1 | FK Ventspils | |
| 15.07.2010 | FK Ventspils | 0-0 | Teteks Tetovo | |
FK Atyrau 0-5 Gyori ETO FC *
| 22.07.2010 | Gyori ETO FC | 2-0 | FK Atyrau | |
| 15.07.2010 | FK Atyrau | 0-3 | Gyori ETO FC | |
*IF Elfsborg 3-1 FC Iskra-Stal
| 22.07.2010 | FC Iskra-Stal | 0-1 | IF Elfsborg | |
| 15.07.2010 | IF Elfsborg | 2-1 | FC Iskra-Stal | |
*Kalmar FF 2-0 Dacia Chisinau
| 22.07.2010 | Dacia Chisinau | 0-2 | Kalmar FF | |
| 15.07.2010 | Kalmar FF | 0-0 | Dacia Chisinau | |
*FC Utrecht 5-1 KF Tirana
| 22.07.2010 | KF Tirana | 1-1 | FC Utrecht | |
| 15.07.2010 | FC Utrecht | 4-0 | KF Tirana | |
KR Reykjavik 2-6 Karpaty Lviv* *
| 22.07.2010 | Karpaty Lviv* | 3-2 | KR Reykjavik | |
| 15.07.2010 | KR Reykjavik | 0-3 | Karpaty Lviv* | |
*Lausanne-Sport 2-1 Borac Banja Luka
| 22.07.2010 | Borac Banja Luka | 1-1 | Lausanne-Sport | |
| 15.07.2010 | Lausanne-Sport | 1-0 | Borac Banja Luka | |
*Levski Sofia 8-0 Dundalk FC
| 22.07.2010 | Dundalk FC | 0-2 | Levski Sofia | |
| 15.07.2010 | Levski Sofia | 6-0 | Dundalk FC | |
*Maccabi Tel Aviv 3-2 FK Mogren
| 22.07.2010 | FK Mogren | 2-1 | Maccabi Tel Aviv | |
| 15.07.2010 | Maccabi Tel Aviv | 2-0 | FK Mogren | |
*Molde FK 2-2 FK Jelgava*
| 22.07.2010 | FK Jelgava* | 2-1 | Molde FK | |
| 15.07.2010 | Molde FK | 1-0 | FK Jelgava* | |
*Motherwell FC 2-0 Breidablik
| 22.07.2010 | Breidablik | 0-1 | Motherwell FC | |
| 15.07.2010 | Motherwell FC | 1-0 | Breidablik | |
*MyPa 8-0 UE Sant Julià
| 23.07.2010 | UE Sant Julià | 0-5 | MyPa | |
| 15.07.2010 | MyPa | 3-0 | UE Sant Julià | |
Besa Kavaje 1-11 Olympiakos Pireus *
| 22.07.2010 | Olympiakos Pireus | 6-1 | Besa Kavaje | |
| 15.07.2010 | Besa Kavaje | 0-5 | Olympiakos Pireus | |
Portadown FC 2-3 Qarabag FK *
| 22.07.2010 | Qarabag FK | 1-1 | Portadown FC | |
| 15.07.2010 | Portadown FC | 1-2 | Qarabag FK | |
*Rabotnicki Skopje 1-0 Mika FC
| 22.07.2010 | Mika FC | 0-0 | Rabotnicki Skopje | |
| 15.07.2010 | Rabotnicki Skopje | 1-0 | Mika FC | |
ND Gorica 1-4 Randers FC *
| 22.07.2010 | Randers FC | 1-1 | ND Gorica | |
| 15.07.2010 | ND Gorica | 0-3 | Randers FC | |
FK Suduva 2-6 Rapid Wien *
| 22.07.2010 | Rapid Wien | 4-2 | FK Suduva | |
| 15.07.2010 | FK Suduva | 0-2 | Rapid Wien | |
Valletta FC 1-1 Ruch Chorzow *
| 22.07.2010 | Ruch Chorzow | 0-0 | Valletta FC | |
| 15.07.2010 | Valletta FC | 1-1 | Ruch Chorzow | |
*Shamrock Rovers 2-1 Bnei Yehuda
| 22.07.2010 | Bnei Yehuda | 0-1 | Shamrock Rovers | |
| 15.07.2010 | Shamrock Rovers | 1-1 | Bnei Yehuda | |
*Anorthosis FC 3-2 Šibenik
| 22.07.2010 | Šibenik | 0-3 AET | Anorthosis FC | |
| 15.07.2010 | Anorthosis FC | 0-2 | Šibenik | |
*Zrinjski Mostar 13-3 SP Tre Penne
| 22.07.2010 | SP Tre Penne | 2-9 | Zrinjski Mostar | |
| 15.07.2010 | Zrinjski Mostar | 4-1 | SP Tre Penne | |
*Marítimo 6-4 Sporting Fingal
| 22.07.2010 | Sporting Fingal | 2-3 | Marítimo | |
| 15.07.2010 | Marítimo | 3-2 | Sporting Fingal | |
*OFK Beograd 3-2 Torpedo Zhodino
| 22.07.2010 | Torpedo Zhodino | 0-1 | OFK Beograd | |
| 15.07.2010 | OFK Beograd | 2-2 | Torpedo Zhodino | |
*Cercle Brugge 2-2 TPS Turku
| 22.07.2010 | TPS Turku | 1-2 | Cercle Brugge | |
| 15.07.2010 | Cercle Brugge | 0-1 | TPS Turku | |
Videoton FC 1-3 Maribor *
| 22.07.2010 | Maribor | 2-0 | Videoton FC | |
| 15.07.2010 | Videoton FC | 1-1 | Maribor | |
FK Siauliai 0-7 Wisła Kraków *
| 22.07.2010 | Wisła Kraków | 5-0 | FK Siauliai | |
| 15.07.2010 | FK Siauliai | 0-2 | Wisła Kraków | |
WIT Georgia 0-6 Banik Ostrava *
| 22.07.2010 | Banik Ostrava | 0-0 | WIT Georgia | |
| 15.07.2010 | WIT Georgia | 0-6 | Banik Ostrava | |