Dynamo Kyiv 1-1 SC Braga *
| 14.04.2011 | SC Braga | 0-0 | Dynamo Kyiv | |
| 07.04.2011 | Dynamo Kyiv | 1-1 | SC Braga | |
*FC Porto 10-3 Spartak Moscow
| 14.04.2011 | Spartak Moscow | 2-5 | FC Porto | |
| 07.04.2011 | FC Porto | 5-1 | Spartak Moscow | |
*SL Benfica 6-3 PSV Eindhoven
| 14.04.2011 | PSV Eindhoven | 2-2 | SL Benfica | |
| 07.04.2011 | SL Benfica | 4-1 | PSV Eindhoven | |
*Villarreal CF 8-2 FC Twente
| 14.04.2011 | FC Twente | 1-3 | Villarreal CF | |
| 07.04.2011 | Villarreal CF | 5-1 | FC Twente | |