*Atlético Madrid 4-2 Hannover 96
| 05.04.2012 | Hannover 96 | 1-2 | Atlético Madrid | |
| 29.03.2012 | Atlético Madrid | 2-1 | Hannover 96 | |
AZ Alkmaar 2-5 Valencia CF *
| 05.04.2012 | Valencia CF | 4-0 | AZ Alkmaar | |
| 29.03.2012 | AZ Alkmaar | 2-1 | Valencia CF | |
Schalke 04 4-6 Athletic Bilbao *
| 05.04.2012 | Athletic Bilbao | 2-2 | Schalke 04 | |
| 29.03.2012 | Schalke 04 | 2-4 | Athletic Bilbao | |
*Sporting Lisboa 3-2 Metalist Kharkiv
| 05.04.2012 | Metalist Kharkiv | 1-1 | Sporting Lisboa | |
| 29.03.2012 | Sporting Lisboa | 2-1 | Metalist Kharkiv | |