*Shakhtar Donetsk 4-1 Anderlecht
| 17.03.2016 | Anderlecht | 0-1 | Shakhtar Donetsk | |
| 10.03.2016 | Shakhtar Donetsk | 3-1 | Anderlecht | |
*Villarreal CF 2-0 Bayer Leverkusen
| 17.03.2016 | Bayer Leverkusen | 0-0 | Villarreal CF | |
| 10.03.2016 | Villarreal CF | 2-0 | Bayer Leverkusen | |
*Borussia Dortmund 5-1 Tottenham
| 17.03.2016 | Tottenham | 1-2 | Borussia Dortmund | |
| 10.03.2016 | Borussia Dortmund | 3-0 | Tottenham | |
FC Basel 0-3 Sevilla FC *
| 17.03.2016 | Sevilla FC | 3-0 | FC Basel | |
| 10.03.2016 | FC Basel | 0-0 | Sevilla FC | |
*Liverpool 3-1 Manchester United
| 17.03.2016 | Manchester United | 1-1 | Liverpool | |
| 10.03.2016 | Liverpool | 2-0 | Manchester United | |
Fenerbahçe SK 2-4 SC Braga *
| 17.03.2016 | SC Braga | 4-1 | Fenerbahçe SK | |
| 10.03.2016 | Fenerbahçe SK | 1-0 | SC Braga | |
*Sparta Praha 4-1 Lazio
| 17.03.2016 | Lazio | 0-3 | Sparta Praha | |
| 10.03.2016 | Sparta Praha | 1-1 | Lazio | |
*Athletic Bilbao 2-2 Valencia CF
| 17.03.2016 | Valencia CF | 2-1 | Athletic Bilbao | |
| 10.03.2016 | Athletic Bilbao | 1-0 | Valencia CF | |