AEK Larnaca 0-4 Slovan Liberec *
| 25.08.2016 | Slovan Liberec | 3-0 | AEK Larnaca | |
| 18.08.2016 | AEK Larnaca | 0-1 | Slovan Liberec | |
Slavia Praha 0-6 Anderlecht *
| 25.08.2016 | Anderlecht | 3-0 | Slavia Praha | |
| 18.08.2016 | Slavia Praha | 0-3 | Anderlecht | |
AS Trenčín 2-4 Rapid Wien *
| 25.08.2016 | Rapid Wien | 0-2 | AS Trenčín | |
| 18.08.2016 | AS Trenčín | 0-4 | Rapid Wien | |
*Austria Wien 4-2 Rosenborg BK
| 25.08.2016 | Rosenborg BK | 1-2 | Austria Wien | |
| 18.08.2016 | Austria Wien | 2-1 | Rosenborg BK | |
*FC Astana 4-2 BATE Borisov
| 25.08.2016 | BATE Borisov | 2-2 | FC Astana | |
| 18.08.2016 | FC Astana | 2-0 | BATE Borisov | |
Beitar Jerusalem 1-2 AS Saint-Étienne *
| 25.08.2016 | AS Saint-Étienne | 0-0 | Beitar Jerusalem | |
| 17.08.2016 | Beitar Jerusalem | 1-2 | AS Saint-Étienne | |
*Panathinaikos 4-1 Brøndby IF
| 25.08.2016 | Brøndby IF | 1-1 | Panathinaikos | |
| 18.08.2016 | Panathinaikos | 3-0 | Brøndby IF | |
Dinamo Tbilisi 0-5 PAOK Salonica *
| 25.08.2016 | PAOK Salonica | 2-0 | Dinamo Tbilisi | |
| 18.08.2016 | Dinamo Tbilisi | 0-3 | PAOK Salonica | |
FC Midtjylland 0-3 Ankaraspor *
| 25.08.2016 | Ankaraspor | 2-0 | FC Midtjylland | |
| 18.08.2016 | FC Midtjylland | 0-1 | Ankaraspor | |
*Sassuolo Calcio 4-1 FK Crvena Zvezda
| 25.08.2016 | FK Crvena Zvezda | 1-1 | Sassuolo Calcio | |
| 18.08.2016 | Sassuolo Calcio | 3-0 | FK Crvena Zvezda | |
FK Vojvodina 0-3 AZ Alkmaar *
| 25.08.2016 | AZ Alkmaar | 0-0 | FK Vojvodina | |
| 18.08.2016 | FK Vojvodina | 0-3 | AZ Alkmaar | |
*Fenerbahçe SK 5-0 Grasshoppers
| 25.08.2016 | Grasshoppers | 0-2 | Fenerbahçe SK | |
| 18.08.2016 | Fenerbahçe SK | 3-0 | Grasshoppers | |
Istanbul Basaksehir 1-4 Shakhtar Donetsk *
| 25.08.2016 | Shakhtar Donetsk | 2-0 | Istanbul Basaksehir | |
| 18.08.2016 | Istanbul Basaksehir | 1-2 | Shakhtar Donetsk | |
*KAA Gent 6-1 Shkendija'79
| 25.08.2016 | Shkendija'79 | 0-4 | KAA Gent | |
| 18.08.2016 | KAA Gent | 2-1 | Shkendija'79 | |
*Maccabi Tel Aviv 3-3 Hajduk Split
| 25.08.2016 | Hajduk Split | 2-1/p.3-4 | Maccabi Tel Aviv | |
| 18.08.2016 | Maccabi Tel Aviv | 2-1 | Hajduk Split | |
FC Arouca 1-3 Olympiakos Pireus *
| 25.08.2016 | Olympiakos Pireus | 2-1 AET | FC Arouca | |
| 18.08.2016 | FC Arouca | 0-1 | Olympiakos Pireus | |
*FK Krasnodar 4-0 Partizani Tirana
| 25.08.2016 | Partizani Tirana | 0-0 | FK Krasnodar | |
| 18.08.2016 | FK Krasnodar | 4-0 | Partizani Tirana | |
IFK Göteborg 1-3 Qarabag FK *
| 25.08.2016 | Qarabag FK | 3-0 | IFK Göteborg | |
| 18.08.2016 | IFK Göteborg | 1-0 | Qarabag FK | |
Lokomotiva Zagreb 2-4 Racing Genk *
| 25.08.2016 | Racing Genk | 2-0 | Lokomotiva Zagreb | |
| 18.08.2016 | Lokomotiva Zagreb | 2-2 | Racing Genk | |
SønderjyskE 2-3 Sparta Praha *
| 25.08.2016 | Sparta Praha | 3-2 | SønderjyskE | |
| 18.08.2016 | SønderjyskE | 0-0 | Sparta Praha | |
*Astra Giurgiu 2-1 West Ham
| 25.08.2016 | West Ham | 0-1 | Astra Giurgiu | |
| 18.08.2016 | Astra Giurgiu | 1-1 | West Ham | |