Ludogorets 0-4 AC Milan *
| 22.02.2018 | AC Milan | 1-0 | Ludogorets | |
| 15.02.2018 | Ludogorets | 0-3 | AC Milan | |
*Borussia Dortmund 4-3 Atalanta Bergamo
| 22.02.2018 | Atalanta Bergamo | 1-1 | Borussia Dortmund | |
| 15.02.2018 | Borussia Dortmund | 3-2 | Atalanta Bergamo | |
FC København 1-5 Atlético Madrid *
| 22.02.2018 | Atlético Madrid | 1-0 | FC København | |
| 15.02.2018 | FC København | 1-4 | Atlético Madrid | |
AEK Athens 1-1 Dynamo Kyiv *
| 22.02.2018 | Dynamo Kyiv | 0-0 | AEK Athens | |
| 15.02.2018 | AEK Athens | 1-1 | Dynamo Kyiv | |
FC Astana 4-6 Sporting Lisboa *
| 22.02.2018 | Sporting Lisboa | 3-3 | FC Astana | |
| 15.02.2018 | FC Astana | 1-3 | Sporting Lisboa | |
FK Crvena Zvezda 0-1 CSKA Moscow *
| 21.02.2018 | CSKA Moscow | 1-0 | FK Crvena Zvezda | |
| 13.02.2018 | FK Crvena Zvezda | 0-0 | CSKA Moscow | |
OGC Nice 2-4 Lokomotiv Moscow *
| 22.02.2018 | Lokomotiv Moscow | 1-0 | OGC Nice | |
| 15.02.2018 | OGC Nice | 2-3 | Lokomotiv Moscow | |
*Olympique Marseille 3-1 SC Braga
| 22.02.2018 | SC Braga | 1-0 | Olympique Marseille | |
| 15.02.2018 | Olympique Marseille | 3-0 | SC Braga | |
Östersunds FK 2-4 Arsenal FC *
| 22.02.2018 | Arsenal FC | 1-2 | Östersunds FK | |
| 15.02.2018 | Östersunds FK | 0-3 | Arsenal FC | |
Real Sociedad 3-4 RB Salzburg *
| 22.02.2018 | RB Salzburg | 2-1 | Real Sociedad | |
| 15.02.2018 | Real Sociedad | 2-2 | RB Salzburg | |
Spartak Moscow 3-4 Athletic Bilbao *
| 22.02.2018 | Athletic Bilbao | 1-2 | Spartak Moscow | |
| 15.02.2018 | Spartak Moscow | 1-3 | Athletic Bilbao | |
SSC Napoli 3-3 RB Leipzig *
| 22.02.2018 | RB Leipzig | 0-2 | SSC Napoli | |
| 15.02.2018 | SSC Napoli | 1-3 | RB Leipzig | |
FK Partizan 1-3 Viktoria Plzen *
| 22.02.2018 | Viktoria Plzen | 2-0 | FK Partizan | |
| 15.02.2018 | FK Partizan | 1-1 | Viktoria Plzen | |
*Lyon 4-1 Villarreal CF
| 22.02.2018 | Villarreal CF | 0-1 | Lyon | |
| 15.02.2018 | Lyon | 3-1 | Villarreal CF | |