AC Milan 1-5 Arsenal FC *
| 15.03.2018 | Arsenal FC | 3-1 | AC Milan | |
| 08.03.2018 | AC Milan | 0-2 | Arsenal FC | |
*Olympique Marseille 5-2 Athletic Bilbao
| 15.03.2018 | Athletic Bilbao | 1-2 | Olympique Marseille | |
| 08.03.2018 | Olympique Marseille | 3-1 | Athletic Bilbao | |
*Atlético Madrid 8-1 Lokomotiv Moscow
| 15.03.2018 | Lokomotiv Moscow | 1-5 | Atlético Madrid | |
| 08.03.2018 | Atlético Madrid | 3-0 | Lokomotiv Moscow | |
*Lazio 4-2 Dynamo Kyiv
| 15.03.2018 | Dynamo Kyiv | 0-2 | Lazio | |
| 08.03.2018 | Lazio | 2-2 | Dynamo Kyiv | |
*CSKA Moscow 3-3 Lyon
| 15.03.2018 | Lyon | 2-3 | CSKA Moscow | |
| 08.03.2018 | CSKA Moscow | 0-1 | Lyon | |
*RB Leipzig 3-2 Zenit
| 15.03.2018 | Zenit | 1-1 | RB Leipzig | |
| 08.03.2018 | RB Leipzig | 2-1 | Zenit | |
Borussia Dortmund 1-2 RB Salzburg *
| 15.03.2018 | RB Salzburg | 0-0 | Borussia Dortmund | |
| 08.03.2018 | Borussia Dortmund | 1-2 | RB Salzburg | |
*Sporting Lisboa 3-2 Viktoria Plzen
| 15.03.2018 | Viktoria Plzen | 2-1 AET | Sporting Lisboa | |
| 08.03.2018 | Sporting Lisboa | 2-0 | Viktoria Plzen | |