*Chelsea FC 8-0 Dynamo Kyiv
| 14.03.2019 | Dynamo Kyiv | 0-5 | Chelsea FC | |
| 07.03.2019 | Chelsea FC | 3-0 | Dynamo Kyiv | |
Dinamo Zagreb 1-3 SL Benfica *
| 14.03.2019 | SL Benfica | 3-0 AET | Dinamo Zagreb | |
| 07.03.2019 | Dinamo Zagreb | 1-0 | SL Benfica | |
*Eintracht Frankfurt 1-0 Inter Milan
| 14.03.2019 | Inter Milan | 0-1 | Eintracht Frankfurt | |
| 07.03.2019 | Eintracht Frankfurt | 0-0 | Inter Milan | |
Sevilla FC 5-6 Slavia Praha *
| 14.03.2019 | Slavia Praha | 4-3 AET | Sevilla FC | |
| 07.03.2019 | Sevilla FC | 2-2 | Slavia Praha | |
*SSC Napoli 4-3 RB Salzburg
| 14.03.2019 | RB Salzburg | 3-1 | SSC Napoli | |
| 07.03.2019 | SSC Napoli | 3-0 | RB Salzburg | |
Stade Rennais 3-4 Arsenal FC *
| 14.03.2019 | Arsenal FC | 3-0 | Stade Rennais | |
| 07.03.2019 | Stade Rennais | 3-1 | Arsenal FC | |
*Valencia CF 3-2 FK Krasnodar
| 14.03.2019 | FK Krasnodar | 1-1 | Valencia CF | |
| 07.03.2019 | Valencia CF | 2-1 | FK Krasnodar | |
Zenit 2-5 Villarreal CF *
| 14.03.2019 | Villarreal CF | 2-1 | Zenit | |
| 07.03.2019 | Zenit | 1-3 | Villarreal CF | |