*Besiktas JK 2-2 LASK Linz
| 16.08.2018 | LASK Linz | 2-1 | Besiktas JK | |
| 09.08.2018 | Besiktas JK | 1-0 | LASK Linz | |
Istanbul Basaksehir 0-1 Burnley *
| 16.08.2018 | Burnley | 1-0 AET | Istanbul Basaksehir | |
| 09.08.2018 | Istanbul Basaksehir | 0-0 | Burnley | |
CSKA Sofia 2-4 FC København *
| 16.08.2018 | FC København | 2-1 | CSKA Sofia | |
| 09.08.2018 | CSKA Sofia | 1-2 | FC København | |
*Apollon Limassol 4-1 Dinamo Brest
| 16.08.2018 | Dinamo Brest | 1-0 | Apollon Limassol | |
| 09.08.2018 | Apollon Limassol | 4-0 | Dinamo Brest | |
Vitesse Arnhem 0-2 FC Basel *
| 16.08.2018 | FC Basel | 1-0 | Vitesse Arnhem | |
| 09.08.2018 | Vitesse Arnhem | 0-1 | FC Basel | |
*Olympiakos Pireus 7-1 FC Luzern
| 16.08.2018 | FC Luzern | 1-3 | Olympiakos Pireus | |
| 09.08.2018 | Olympiakos Pireus | 4-0 | FC Luzern | |
FC Mariupol 2-5 Girondins Bordeaux *
| 16.08.2018 | Girondins Bordeaux | 2-1 | FC Mariupol | |
| 09.08.2018 | FC Mariupol | 1-3 | Girondins Bordeaux | |
FC Nordsjælland 3-5 FK Partizan *
| 16.08.2018 | FK Partizan | 3-2 | FC Nordsjælland | |
| 09.08.2018 | FC Nordsjælland | 1-2 | FK Partizan | |
Hajduk Split 1-2 FCSB *
| 16.08.2018 | FCSB | 2-1 | Hajduk Split | |
| 09.08.2018 | Hajduk Split | 0-0 | FCSB | |
*AS Trenčín 5-1 Feyenoord
| 16.08.2018 | Feyenoord | 1-1 | AS Trenčín | |
| 09.08.2018 | AS Trenčín | 4-0 | Feyenoord | |
Hapoel Haifa 1-6 Atalanta Bergamo *
| 16.08.2018 | Atalanta Bergamo | 2-0 | Hapoel Haifa | |
| 09.08.2018 | Hapoel Haifa | 1-4 | Atalanta Bergamo | |
Hibernian FC 0-3 Molde FK *
| 16.08.2018 | Molde FK | 3-0 | Hibernian FC | |
| 09.08.2018 | Hibernian FC | 0-0 | Molde FK | |
Jagiellonia 1-4 KAA Gent *
| 16.08.2018 | KAA Gent | 3-1 | Jagiellonia | |
| 09.08.2018 | Jagiellonia | 0-1 | KAA Gent | |
*Racing Genk 4-1 Lech Poznan
| 16.08.2018 | Lech Poznan | 1-2 | Racing Genk | |
| 09.08.2018 | Racing Genk | 2-0 | Lech Poznan | |
Pyunik FC 1-2 Maccabi Tel Aviv *
| 16.08.2018 | Maccabi Tel Aviv | 2-1 | Pyunik FC | |
| 07.08.2018 | Pyunik FC | 0-0 | Maccabi Tel Aviv | |
*Rangers FC 3-1 Maribor
| 16.08.2018 | Maribor | 0-0 | Rangers FC | |
| 09.08.2018 | Rangers FC | 3-1 | Maribor | |
*FK Ufa 4-3 Progrès Niedercorn
| 16.08.2018 | Progrès Niedercorn | 2-2 | FK Ufa | |
| 09.08.2018 | FK Ufa | 2-1 | Progrès Niedercorn | |
*RB Leipzig 4-2 Universitatea Craiova
| 16.08.2018 | Universitatea Craiova | 1-1 | RB Leipzig | |
| 09.08.2018 | RB Leipzig | 3-1 | Universitatea Craiova | |
*Sarpsborg 08 2-1 HNK Rijeka
| 16.08.2018 | HNK Rijeka | 0-1 | Sarpsborg 08 | |
| 09.08.2018 | Sarpsborg 08 | 1-1 | HNK Rijeka | |
*Zorya Luhansk 3-3 SC Braga
| 16.08.2018 | SC Braga | 2-2 | Zorya Luhansk | |
| 09.08.2018 | Zorya Luhansk | 1-1 | SC Braga | |
Sigma Olomouc 4-1 Kairat Almaty
| 16.08.2018 | Kairat Almaty | 1-2 | Sigma Olomouc | |
| 09.08.2018 | Sigma Olomouc | 2-0 | Kairat Almaty | |
Slovan Bratislava 2-5 Rapid Wien *
| 16.08.2018 | Rapid Wien | 4-0 | Slovan Bratislava | |
| 09.08.2018 | Slovan Bratislava | 2-1 | Rapid Wien | |
Spartak Subotica 1-4 Brøndby IF *
| 16.08.2018 | Brøndby IF | 2-1 | Spartak Subotica | |
| 09.08.2018 | Spartak Subotica | 0-2 | Brøndby IF | |
Sturm Graz 0-7 AEK Larnaca *
| 16.08.2018 | AEK Larnaca | 5-0 | Sturm Graz | |
| 09.08.2018 | Sturm Graz | 0-2 | AEK Larnaca | |
*Sevilla FC 6-0 VMFD Zalgiris
| 16.08.2018 | VMFD Zalgiris | 0-5 | Sevilla FC | |
| 09.08.2018 | Sevilla FC | 1-0 | VMFD Zalgiris | |
Dinamo Minsk 5-8 Zenit *
| 16.08.2018 | Zenit | 8-1 AET | Dinamo Minsk | |
| 09.08.2018 | Dinamo Minsk | 4-0 | Zenit | |