FK Crvena Zvezda 3-3 AC Milan *
| 25.02.2021 | AC Milan | 1-1 | FK Crvena Zvezda | |
| 18.02.2021 | FK Crvena Zvezda | 2-2 | AC Milan | |
*BSC Young Boys 6-3 Bayer Leverkusen
| 25.02.2021 | Bayer Leverkusen | 0-2 | BSC Young Boys | |
| 18.02.2021 | BSC Young Boys | 4-3 | Bayer Leverkusen | |
FK Krasnodar 2-4 Dinamo Zagreb *
| 25.02.2021 | Dinamo Zagreb | 1-0 | FK Krasnodar | |
| 18.02.2021 | FK Krasnodar | 2-3 | Dinamo Zagreb | |
*Dynamo Kyiv 2-1 Club Brugge
| 25.02.2021 | Club Brugge | 0-1 | Dynamo Kyiv | |
| 18.02.2021 | Dynamo Kyiv | 1-1 | Club Brugge | |
*Granada CF 3-2 SSC Napoli
| 25.02.2021 | SSC Napoli | 2-1 | Granada CF | |
| 18.02.2021 | Granada CF | 2-0 | SSC Napoli | |
*Molde FK 5-3 Hoffenheim
| 25.02.2021 | Hoffenheim | 0-2 | Molde FK | |
| 18.02.2021 | Molde FK | 3-3 | Hoffenheim | |
Real Sociedad 0-4 Manchester United *
| 25.02.2021 | Manchester United | 0-0 | Real Sociedad | |
| 18.02.2021 | Real Sociedad | 0-4 | Manchester United | |
*Olympiakos Pireus 5-4 PSV Eindhoven
| 25.02.2021 | PSV Eindhoven | 2-1 | Olympiakos Pireus | |
| 18.02.2021 | Olympiakos Pireus | 4-2 | PSV Eindhoven | |
Royal Antwerp 5-9 Rangers FC *
| 25.02.2021 | Rangers FC | 5-2 | Royal Antwerp | |
| 18.02.2021 | Royal Antwerp | 3-4 | Rangers FC | |
Maccabi Tel Aviv 0-3 Shakhtar Donetsk *
| 25.02.2021 | Shakhtar Donetsk | 1-0 | Maccabi Tel Aviv | |
| 18.02.2021 | Maccabi Tel Aviv | 0-2 | Shakhtar Donetsk | |
SL Benfica 3-4 Arsenal FC *
| 25.02.2021 | Arsenal FC | 3-2 | SL Benfica | |
| 18.02.2021 | SL Benfica | 1-1 | Arsenal FC | |
*Slavia Praha 2-0 Leicester City
| 25.02.2021 | Leicester City | 0-2 | Slavia Praha | |
| 18.02.2021 | Slavia Praha | 0-0 | Leicester City | |
RB Salzburg 1-4 Villarreal CF *
| 25.02.2021 | Villarreal CF | 2-1 | RB Salzburg | |
| 18.02.2021 | RB Salzburg | 0-2 | Villarreal CF | |
Wolfsberger AC 1-8 Tottenham *
| 24.02.2021 | Tottenham | 4-0 | Wolfsberger AC | |
| 18.02.2021 | Wolfsberger AC | 1-4 | Tottenham | |