*Manchester United 2-1 AC Milan
| 18.03.2021 | AC Milan | 0-1 | Manchester United | |
| 11.03.2021 | Manchester United | 1-1 | AC Milan | |
*AFC Ajax 5-0 BSC Young Boys
| 18.03.2021 | BSC Young Boys | 0-2 | AFC Ajax | |
| 11.03.2021 | AFC Ajax | 3-0 | BSC Young Boys | |
Olympiakos Pireus 2-3 Arsenal FC *
| 18.03.2021 | Arsenal FC | 0-1 | Olympiakos Pireus | |
| 11.03.2021 | Olympiakos Pireus | 1-3 | Arsenal FC | |
*AS Roma 5-1 Shakhtar Donetsk
| 18.03.2021 | Shakhtar Donetsk | 1-2 | AS Roma | |
| 11.03.2021 | AS Roma | 3-0 | Shakhtar Donetsk | |
Dynamo Kyiv 0-4 Villarreal CF *
| 18.03.2021 | Villarreal CF | 2-0 | Dynamo Kyiv | |
| 11.03.2021 | Dynamo Kyiv | 0-2 | Villarreal CF | |
*Granada CF 3-2 Molde FK
| 18.03.2021 | Molde FK | 2-1 | Granada CF | |
| 11.03.2021 | Granada CF | 2-0 | Molde FK | |
*Slavia Praha 3-1 Rangers FC
| 18.03.2021 | Rangers FC | 0-2 | Slavia Praha | |
| 11.03.2021 | Slavia Praha | 1-1 | Rangers FC | |
Tottenham 2-3 Dinamo Zagreb *
| 18.03.2021 | Dinamo Zagreb | 3-0 AET | Tottenham | |
| 11.03.2021 | Tottenham | 2-0 | Dinamo Zagreb | |