Union Saint-Gilloise 2-3 AFC Ajax *
| 20.02.2025 | AFC Ajax | 1-2 AET | Union Saint-Gilloise | |
| 13.02.2025 | Union Saint-Gilloise | 0-2 | AFC Ajax | |
*Fenerbahçe SK 5-2 Anderlecht
| 20.02.2025 | Anderlecht | 2-2 | Fenerbahçe SK | |
| 13.02.2025 | Fenerbahçe SK | 3-0 | Anderlecht | |
*AZ Alkmaar 6-3 Galatasaray SK
| 20.02.2025 | Galatasaray SK | 2-2 | AZ Alkmaar | |
| 13.02.2025 | AZ Alkmaar | 4-1 | Galatasaray SK | |
FC Twente 4-6 FK Bodo/Glimt *
| 20.02.2025 | FK Bodo/Glimt | 5-2 AET | FC Twente | |
| 13.02.2025 | FC Twente | 2-1 | FK Bodo/Glimt | |
PAOK Salonica 1-4 FCSB *
| 20.02.2025 | FCSB | 2-0 | PAOK Salonica | |
| 13.02.2025 | PAOK Salonica | 1-2 | FCSB | |
FC Midtjylland 3-7 Real Sociedad *
| 20.02.2025 | Real Sociedad | 5-2 | FC Midtjylland | |
| 13.02.2025 | FC Midtjylland | 1-2 | Real Sociedad | |
Ferencvaros TC 1-3 Viktoria Plzen *
| 20.02.2025 | Viktoria Plzen | 3-0 | Ferencvaros TC | |
| 13.02.2025 | Ferencvaros TC | 1-0 | Viktoria Plzen | |