Austria Wien 3-3 Real Zaragoza
| 17.03.2005 | Real Zaragoza | 2-2 | Austria Wien | |
| 10.03.2005 | Austria Wien | 1-1 | Real Zaragoza | |
FK Partizan 1-3 CSKA Moscow
| 17.03.2005 | CSKA Moscow | 2-0 | FK Partizan | |
| 10.03.2005 | FK Partizan | 1-1 | CSKA Moscow | |
Lille OSC 0-1 AJ Auxerre
| 17.03.2005 | AJ Auxerre | 0-0 | Lille OSC | |
| 10.03.2005 | Lille OSC | 0-1 | AJ Auxerre | |
Olympiakos Pireus 1-7 Newcastle United
| 16.03.2005 | Newcastle United | 4-0 | Olympiakos Pireus | |
| 10.03.2005 | Olympiakos Pireus | 1-3 | Newcastle United | |
Sevilla FC 0-1 Parma FC
| 17.03.2005 | Parma FC | 1-0 | Sevilla FC | |
| 10.03.2005 | Sevilla FC | 0-0 | Parma FC | |
Shakhtar Donetsk 2-5 AZ Alkmaar
| 16.03.2005 | AZ Alkmaar | 2-1 | Shakhtar Donetsk | |
| 10.03.2005 | Shakhtar Donetsk | 1-3 | AZ Alkmaar | |
Middlesbrough 2-4 Sporting Lisboa
| 17.03.2005 | Sporting Lisboa | 1-0 | Middlesbrough | |
| 10.03.2005 | Middlesbrough | 2-3 | Sporting Lisboa | |
Steaua Bucuresti 0-2 Villarreal CF
| 20.03.2005 | Villarreal CF | 2-0 | Steaua Bucuresti | |
| 16.03.2005 | Steaua Bucuresti | 0-0 | Villarreal CF | |