Club Brugge 2-4 AS Roma
| 23.02.2006 | AS Roma | 2-1 | Club Brugge | |
| 15.02.2006 | Club Brugge | 1-2 | AS Roma | |
FC Artmedia Bratislava 0-3 Levski Sofia
| 23.02.2006 | Levski Sofia | 2-0 | FC Artmedia Bratislava | |
| 15.02.2006 | FC Artmedia Bratislava | 0-1 | Levski Sofia | |
FC Thun 1-2 Hamburger SV
| 23.02.2006 | Hamburger SV | 2-0 | FC Thun | |
| 16.02.2006 | FC Thun | 1-0 | Hamburger SV | |
Lille OSC 3-2 Shakhtar Donetsk
| 23.02.2006 | Shakhtar Donetsk | 0-0 | Lille OSC | |
| 15.02.2006 | Lille OSC | 3-2 | Shakhtar Donetsk | |
Litex Lovech 0-2 Strasbourg
| 23.02.2006 | Strasbourg | 0-0 | Litex Lovech | |
| 15.02.2006 | Litex Lovech | 0-2 | Strasbourg | |
VfB Stuttgart 2-2 Middlesbrough
| 23.02.2006 | Middlesbrough | 0-1 | VfB Stuttgart | |
| 16.02.2006 | VfB Stuttgart | 1-2 | Middlesbrough | |
Bolton Wanderers 1-2 Olympique Marseille
| 23.02.2006 | Olympique Marseille | 2-1 | Bolton Wanderers | |
| 15.02.2006 | Bolton Wanderers | 0-0 | Olympique Marseille | |
Slavia Praha 2-2 Palermo
| 23.02.2006 | Palermo | 1-0 | Slavia Praha | |
| 16.02.2006 | Slavia Praha | 2-1 | Palermo | |
Hertha BSC 0-3 Rapid Bucuresti
| 23.02.2006 | Rapid Bucuresti | 2-0 | Hertha BSC | |
| 15.02.2006 | Hertha BSC | 0-1 | Rapid Bucuresti | |
Real Betis 3-2 AZ Alkmaar
| 23.02.2006 | AZ Alkmaar | 2-1 AET | Real Betis | |
| 15.02.2006 | Real Betis | 2-0 | AZ Alkmaar | |
Schalke 04 5-1 RCD Espanyol
| 23.02.2006 | RCD Espanyol | 0-3 | Schalke 04 | |
| 15.02.2006 | Schalke 04 | 2-1 | RCD Espanyol | |
Lokomotiv Moscow 0-3 Sevilla FC
| 23.02.2006 | Sevilla FC | 2-0 | Lokomotiv Moscow | |
| 15.02.2006 | Lokomotiv Moscow | 0-1 | Sevilla FC | |
SC Heerenveen 2-3 Steaua Bucuresti
| 23.02.2006 | Steaua Bucuresti | 0-1 | SC Heerenveen | |
| 15.02.2006 | SC Heerenveen | 1-3 | Steaua Bucuresti | |
Udinese Calcio 3-1 RC Lens
| 23.02.2006 | RC Lens | 1-0 | Udinese Calcio | |
| 15.02.2006 | Udinese Calcio | 3-0 | RC Lens | |
Rosenborg BK 1-4 Zenit
| 23.02.2006 | Zenit | 2-1 | Rosenborg BK | |
| 15.02.2006 | Rosenborg BK | 0-2 | Zenit | |