FC Basel 4-2 Strasbourg
| 16.03.2006 | Strasbourg | 2-2 | FC Basel | |
| 09.03.2006 | FC Basel | 2-0 | Strasbourg | |
Rapid Bucuresti 3-3 Hamburger SV
| 15.03.2006 | Hamburger SV | 3-1 | Rapid Bucuresti | |
| 09.03.2006 | Rapid Bucuresti | 2-0 | Hamburger SV | |
Middlesbrough 2-2 AS Roma
| 15.03.2006 | AS Roma | 2-1 | Middlesbrough | |
| 09.03.2006 | Middlesbrough | 1-0 | AS Roma | |
Steaua Bucuresti 3-0 Real Betis
| 16.03.2006 | Real Betis | 0-3 | Steaua Bucuresti | |
| 09.03.2006 | Steaua Bucuresti | 0-0 | Real Betis | |
Palermo 1-3 Schalke 04
| 16.03.2006 | Schalke 04 | 3-0 | Palermo | |
| 09.03.2006 | Palermo | 1-0 | Schalke 04 | |
Lille OSC 1-2 Sevilla FC
| 15.03.2006 | Sevilla FC | 2-0 | Lille OSC | |
| 09.03.2006 | Lille OSC | 1-0 | Sevilla FC | |
Udinese Calcio 1-2 Levski Sofia
| 16.03.2006 | Levski Sofia | 2-1 | Udinese Calcio | |
| 09.03.2006 | Udinese Calcio | 0-0 | Levski Sofia | |
Olympique Marseille 1-2 Zenit
| 16.03.2006 | Zenit | 1-1 | Olympique Marseille | |
| 09.03.2006 | Olympique Marseille | 0-1 | Zenit | |