*AEK Athens 3-1 RB Salzburg
| 04.10.2007 | RB Salzburg | 1-0 | AEK Athens | |
| 20.09.2007 | AEK Athens | 3-0 | RB Salzburg | |
*Dinamo Zagreb 3-3 AFC Ajax
| 04.10.2007 | AFC Ajax | 2-3 AET | Dinamo Zagreb | |
| 20.09.2007 | Dinamo Zagreb | 0-1 | AFC Ajax | |
*Anderlecht 2-1 Rapid Wien
| 04.10.2007 | Rapid Wien | 0-1 | Anderlecht | |
| 20.09.2007 | Anderlecht | 1-1 | Rapid Wien | |
*Aris Salonica 2-2 Real Zaragoza
| 04.10.2007 | Real Zaragoza | 2-1 | Aris Salonica | |
| 20.09.2007 | Aris Salonica | 1-0 | Real Zaragoza | |
*Bayer Leverkusen 5-4 Uniao Leiria
| 04.10.2007 | Uniao Leiria | 3-2 | Bayer Leverkusen | |
| 20.09.2007 | Bayer Leverkusen | 3-1 | Uniao Leiria | |
*Bayern München 3-0 Belenenses
| 04.10.2007 | Belenenses | 0-2 | Bayern München | |
| 20.09.2007 | Bayern München | 1-0 | Belenenses | |
*Spartak Moscow 8-1 BK Häcken
| 04.10.2007 | BK Häcken | 1-3 | Spartak Moscow | |
| 20.09.2007 | Spartak Moscow | 5-0 | BK Häcken | |
*AE Larisa 3-2 Blackburn Rovers
| 04.10.2007 | Blackburn Rovers | 2-1 | AE Larisa | |
| 20.09.2007 | AE Larisa | 2-0 | Blackburn Rovers | |
Rabotnicki Skopje 1-2 Bolton Wanderers *
| 04.10.2007 | Bolton Wanderers | 1-0 | Rabotnicki Skopje | |
| 20.09.2007 | Rabotnicki Skopje | 1-1 | Bolton Wanderers | |
*SK Brann 2-2 Club Brugge
| 04.10.2007 | Club Brugge | 1-2 | SK Brann | |
| 20.09.2007 | SK Brann | 0-1 | Club Brugge | |
*Toulouse FC 1-1 CSKA Sofia
| 04.10.2007 | CSKA Sofia | 1-1 | Toulouse FC | |
| 20.09.2007 | Toulouse FC | 0-0 | CSKA Sofia | |
*Aberdeen FC 1-1 Dnipro
| 04.10.2007 | Dnipro | 1-1 | Aberdeen FC | |
| 20.09.2007 | Aberdeen FC | 0-0 | Dnipro | |
FC Artmedia Petržalka 1-5 Panathinaikos
| 02.10.2007 | Panathinaikos | 3-0 | FC Artmedia Petržalka | |
| 20.09.2007 | FC Artmedia Petržalka | 1-2 | Panathinaikos | |
FK Sarajevo 1-8 FC Basel *
| 04.10.2007 | FC Basel | 6-0 | FK Sarajevo | |
| 20.09.2007 | FK Sarajevo | 1-2 | FC Basel | |
FC Groningen 2-2 Fiorentina *
| 04.10.2007 | Fiorentina | 1-1/p.4-3 | FC Groningen | |
| 20.09.2007 | FC Groningen | 1-1 | Fiorentina | |
RC Lens 2-3 FC København *
| 04.10.2007 | FC København | 2-1 AET | RC Lens | |
| 19.09.2007 | RC Lens | 1-1 | FC København | |
FC Sochaux 1-2 Panionios GSS *
| 04.10.2007 | Panionios GSS | 0-1 | FC Sochaux | |
| 20.09.2007 | FC Sochaux | 0-2 | Panionios GSS | |
Groclin 0-2 FK Crvena Zvezda *
| 04.10.2007 | FK Crvena Zvezda | 1-0 | Groclin | |
| 20.09.2007 | Groclin | 0-1 | FK Crvena Zvezda | |
FC Sion 4-7 Galatasaray SK *
| 04.10.2007 | Galatasaray SK | 5-1 | FC Sion | |
| 20.09.2007 | FC Sion | 3-2 | Galatasaray SK | |
Tampere Utd 3-4 Girondins Bordeaux *
| 04.10.2007 | Girondins Bordeaux | 1-1 | Tampere Utd | |
| 20.09.2007 | Tampere Utd | 2-3 | Girondins Bordeaux | |
Litex Lovech 1-4 Hamburger SV *
| 04.10.2007 | Hamburger SV | 3-1 | Litex Lovech | |
| 18.09.2007 | Litex Lovech | 0-1 | Hamburger SV | |
Hammarby IF 2-5 SC Braga *
| 04.10.2007 | SC Braga | 4-0 | Hammarby IF | |
| 20.09.2007 | Hammarby IF | 2-1 | SC Braga | |
*Hapoel Tel Aviv 1-0 AIK Fotboll
| 04.10.2007 | AIK Fotboll | 0-1 | Hapoel Tel Aviv | |
| 20.09.2007 | Hapoel Tel Aviv | 0-0 | AIK Fotboll | |
SC Heerenveen 6-8 Helsingborg *
| 04.10.2007 | Helsingborg | 5-1 | SC Heerenveen | |
| 20.09.2007 | SC Heerenveen | 5-3 | Helsingborg | |
Dinamo Bucuresti 2-2 IF Elfsborg *
| 04.10.2007 | IF Elfsborg | 0-1 | Dinamo Bucuresti | |
| 20.09.2007 | Dinamo Bucuresti | 1-2 | IF Elfsborg | |
*Atlético Madrid 9-0 Kayseri Erciyesspor
| 04.10.2007 | Kayseri Erciyesspor | 0-5 | Atlético Madrid | |
| 20.09.2007 | Atlético Madrid | 4-0 | Kayseri Erciyesspor | |
FC Midtjylland 1-5 Lokomotiv Moscow *
| 04.10.2007 | Lokomotiv Moscow | 2-0 | FC Midtjylland | |
| 20.09.2007 | FC Midtjylland | 1-3 | Lokomotiv Moscow | |
*Everton 4-3 Metalist Kharkiv
| 04.10.2007 | Metalist Kharkiv | 2-3 | Everton | |
| 20.09.2007 | Everton | 1-1 | Metalist Kharkiv | |
*Mlada Boleslav 1-1 Palermo
| 04.10.2007 | Palermo | 0-1/p.2-4 | Mlada Boleslav | |
| 20.09.2007 | Mlada Boleslav | 0-1 | Palermo | |
*Nürnberg 2-2 Rapid Bucuresti
| 04.10.2007 | Rapid Bucuresti | 2-2 | Nürnberg | |
| 20.09.2007 | Nürnberg | 0-0 | Rapid Bucuresti | |
*Sparta Praha 0-0 Odense BK
| 04.10.2007 | Odense BK | 0-0/p.3-4 | Sparta Praha | |
| 20.09.2007 | Sparta Praha | 0-0 | Odense BK | |
Paços de Ferreira 0-1 AZ Alkmaar *
| 04.10.2007 | AZ Alkmaar | 0-0 | Paços de Ferreira | |
| 20.09.2007 | Paços de Ferreira | 0-1 | AZ Alkmaar | |
Sampdoria 2-2 AaB Aalborg *
| 04.10.2007 | AaB Aalborg | 0-0 | Sampdoria | |
| 20.09.2007 | Sampdoria | 2-2 | AaB Aalborg | |
Lokomotiv Sofia 3-4 Stade Rennais *
| 04.10.2007 | Stade Rennais | 1-2 | Lokomotiv Sofia | |
| 20.09.2007 | Lokomotiv Sofia | 1-3 | Stade Rennais | |
*Zenit 4-1 Standard Liège
| 04.10.2007 | Standard Liège | 1-1 | Zenit | |
| 20.09.2007 | Zenit | 3-0 | Standard Liège | |
*Tottenham 7-2 Anorthosis FC
| 04.10.2007 | Anorthosis FC | 1-1 | Tottenham | |
| 20.09.2007 | Tottenham | 6-1 | Anorthosis FC | |
*Austria Wien 4-2 Valerenga
| 04.10.2007 | Valerenga | 2-2 | Austria Wien | |
| 20.09.2007 | Austria Wien | 2-0 | Valerenga | |
*Villarreal CF 6-1 BATE Borisov
| 04.10.2007 | BATE Borisov | 0-2 | Villarreal CF | |
| 20.09.2007 | Villarreal CF | 4-1 | BATE Borisov | |