Schalke Youth 2-5 AFC Ajax Youth *
| 21.10.2015 | AFC Ajax Youth | 2-0 | Schalke Youth | |
| 30.09.2015 | Schalke Youth | 2-3 | AFC Ajax Youth | |
APOEL FC Youth 4-9 Puskás Akadémia U19 *
| 21.10.2015 | Puskás Akadémia U19 | 6-1 | APOEL FC Youth | |
| 30.09.2015 | APOEL FC Youth | 3-3 | Puskás Akadémia U19 | |
FK Aktobe Youth 0-6 Besiktas Youth *
| 21.10.2015 | Besiktas Youth | 4-0 | FK Aktobe Youth | |
| 30.09.2015 | FK Aktobe Youth | 0-2 | Besiktas Youth | |
*FK Rad Youth 1-1 Domžale Youth
| 20.10.2015 | Domžale Youth | 0-1/p.2-3 | FK Rad Youth | |
| 30.09.2015 | FK Rad Youth | 0-1 | Domžale Youth | |
FK Minsk Youth 3-7 Viitorul C. Youth *
| 21.10.2015 | Viitorul C. Youth | 5-1 | FK Minsk Youth | |
| 29.09.2015 | FK Minsk Youth | 2-2 | Viitorul C. Youth | |
FK Senica Youth 1-2 Torino Youth *
| 21.10.2015 | Torino Youth | 2-1 | FK Senica Youth | |
| 29.09.2015 | FK Senica Youth | 0-0 | Torino Youth | |
HJK Helsinki Youth 1-6 Celtic FC Youth *
| 20.10.2015 | Celtic FC Youth | 1-1 | HJK Helsinki Youth | |
| 30.09.2015 | HJK Helsinki Youth | 0-5 | Celtic FC Youth | |
*IF Elfsborg U19 2-1 Stjarnan Youth
| 21.10.2015 | Stjarnan Youth | 1-0 | IF Elfsborg U19 | |
| 30.09.2015 | IF Elfsborg U19 | 2-0 | Stjarnan Youth | |
Litex Lovech Youth 2-5 Legia Youth *
| 20.10.2015 | Legia Youth | 3-1 | Litex Lovech Youth | |
| 30.09.2015 | Litex Lovech Youth | 1-2 | Legia Youth | |
Stade Reims Youth 5-6 Middlesbrough Youth *
| 21.10.2015 | Middlesbrough Youth | 3-0 | Stade Reims Youth | |
| 30.09.2015 | Stade Reims Youth | 5-3 | Middlesbrough Youth | |
*Midtjylland Youth 5-2 Saburtalo Youth
| 21.10.2015 | Saburtalo Youth | 1-2 | Midtjylland Youth | |
| 30.09.2015 | Midtjylland Youth | 3-1 | Saburtalo Youth | |
*RB Salzburg Youth 5-2 Zeljeznicar Youth
| 14.10.2015 | Zeljeznicar Youth | 2-1 | RB Salzburg Youth | |
| 30.09.2015 | RB Salzburg Youth | 4-0 | Zeljeznicar Youth | |
Villarreal Youth 4-4 Servette U21 *
| 21.10.2015 | Servette U21 | 1-2 | Villarreal Youth | |
| 30.09.2015 | Villarreal Youth | 2-3 | Servette U21 | |
SK Brann Youth 1-6 Anderlecht Youth *
| 07.10.2015 | Anderlecht Youth | 5-0 | SK Brann Youth | |
| 30.09.2015 | SK Brann Youth | 1-1 | Anderlecht Youth | |
*Spartak M. Youth 4-0 Ravan Baku Youth
| 21.10.2015 | Ravan Baku Youth | 0-0 | Spartak M. Youth | |
| 30.09.2015 | Spartak M. Youth | 4-0 | Ravan Baku Youth | |
*Pribram Youth 4-1 Zimbru Youth
| 21.10.2015 | Zimbru Youth | 1-2 | Pribram Youth | |
| 30.09.2015 | Pribram Youth | 2-0 | Zimbru Youth | |