AEL Limassol Youth 1-4 PAOK Youth *
| 24.10.2018 | PAOK Youth | 2-0 | AEL Limassol Youth | |
| 03.10.2018 | AEL Limassol Youth | 1-2 | PAOK Youth | |
*Anderlecht Youth 1-1 Admira Youth
| 23.10.2018 | Admira Youth | 1-1 | Anderlecht Youth | |
| 03.10.2018 | Anderlecht Youth | 0-0 | Admira Youth | |
*Midtjylland Youth 4-2 Bohemians Youth
| 24.10.2018 | Bohemians Youth | 1-2 | Midtjylland Youth | |
| 03.10.2018 | Midtjylland Youth | 2-1 | Bohemians Youth | |
*Chelsea FC Youth 14-1 Molde Youth
| 24.10.2018 | Molde Youth | 0-4 | Chelsea FC Youth | |
| 03.10.2018 | Chelsea FC Youth | 10-1 | Molde Youth | |
*Dinamo Minsk Youth 4-3 Illés Akadémia Haladas U19
| 24.10.2018 | Illés Akadémia Haladas U19 | 3-3 | Dinamo Minsk Youth | |
| 03.10.2018 | Dinamo Minsk Youth | 1-0 | Illés Akadémia Haladas U19 | |
*Dynamo Kyiv Youth 6-1 Septemvri Youth
| 24.10.2018 | Septemvri Youth | 1-5 | Dynamo Kyiv Youth | |
| 03.10.2018 | Dynamo Kyiv Youth | 1-0 | Septemvri Youth | |
*FC Astana Youth 7-1 Vllaznia Youth
| 24.10.2018 | Vllaznia Youth | 0-4 | FC Astana Youth | |
| 04.10.2018 | FC Astana Youth | 3-1 | Vllaznia Youth | |
FC Basel Youth 4-4 Hamilton Youth *
| 24.10.2018 | Hamilton Youth | 2-2/p.3-2 | FC Basel Youth | |
| 03.10.2018 | FC Basel Youth | 2-2 | Hamilton Youth | |
*Altınordu SK Youth 3-2 HJK Helsinki Youth
| 24.10.2018 | HJK Helsinki Youth | 1-2 | Altınordu SK Youth | |
| 03.10.2018 | Altınordu SK Youth | 1-1 | HJK Helsinki Youth | |
KR Reykjavik Youth 1-3 IF Elfsborg U19 *
| 24.10.2018 | IF Elfsborg U19 | 1-0 | KR Reykjavik Youth | |
| 03.10.2018 | KR Reykjavik Youth | 1-2 | IF Elfsborg U19 | |
*Hertha BSC U19 5-2 Lech P. Youth
| 24.10.2018 | Lech P. Youth | 2-3 | Hertha BSC U19 | |
| 03.10.2018 | Hertha BSC U19 | 2-0 | Lech P. Youth | |
Anzhi Youth 3-5 Maccabi Youth
| 24.10.2018 | Maccabi Youth | 3-0 | Anzhi Youth | |
| 03.10.2018 | Anzhi Youth | 3-2 | Maccabi Youth | |
*Sigma Olomouc Youth 7-3 Maribor Youth
| 24.10.2018 | Maribor Youth | 2-3 | Sigma Olomouc Youth | |
| 03.10.2018 | Sigma Olomouc Youth | 4-1 | Maribor Youth | |
MSK Zilina Youth 1-7 Montpellier Youth *
| 24.10.2018 | Montpellier Youth | 2-0 | MSK Zilina Youth | |
| 03.10.2018 | MSK Zilina Youth | 1-5 | Montpellier Youth | |
*Gabala FC Youth 4-2 Sheriff Tiraspol Youth
| 24.10.2018 | Sheriff Tiraspol Youth | 1-3 | Gabala FC Youth | |
| 03.10.2018 | Gabala FC Youth | 1-1 | Sheriff Tiraspol Youth | |
Viitorul C. Youth 0-3 Dinamo Zagreb Youth
| 23.10.2018 | Dinamo Zagreb Youth | 2-0 | Viitorul C. Youth | |
| 02.10.2018 | Viitorul C. Youth | 0-1 | Dinamo Zagreb Youth | |