1.FC Köln U19 3-7 Racing Genk Youth *
| 19.10.2021 | Racing Genk Youth | 3-1 | 1.FC Köln U19 | |
| 29.09.2021 | 1.FC Köln U19 | 2-4 | Racing Genk Youth | |
*Septemvri Youth 4-1 Akademia e Futbollit Youth
| 19.10.2021 | Akademia e Futbollit Youth | 1-1 | Septemvri Youth | |
| 29.09.2021 | Septemvri Youth | 3-0 | Akademia e Futbollit Youth | |
FK Csikszereda Youth 0-5 Angers SCO Youth *
| 20.10.2021 | Angers SCO Youth | 3-0 | FK Csikszereda Youth | |
| 29.09.2021 | FK Csikszereda Youth | 0-2 | Angers SCO Youth | |
Gabala FC Youth 0-11 AZ Alkmaar Youth *
| 19.10.2021 | AZ Alkmaar Youth | 7-0 | Gabala FC Youth | |
| 29.09.2021 | Gabala FC Youth | 0-4 | AZ Alkmaar Youth | |
BFC Daugavpils Youth 0-6 Dinamo Minsk Youth *
| 20.10.2021 | Dinamo Minsk Youth | 2-0 | BFC Daugavpils Youth | |
| 29.09.2021 | BFC Daugavpils Youth | 0-4 | Dinamo Minsk Youth | |
St Patrick's Dublin Youth 1-4 Crvena Zvezda Youth *
| 20.10.2021 | Crvena Zvezda Youth | 2-0 | St Patrick's Dublin Youth | |
| 29.09.2021 | St Patrick's Dublin Youth | 1-2 | Crvena Zvezda Youth | |
Domžale Youth 2-3 Empoli Youth *
| 20.10.2021 | Empoli Youth | 1-1 | Domžale Youth | |
| 29.09.2021 | Domžale Youth | 1-2 | Empoli Youth | |
Shkendija'79 Youth 1-5 Hajduk Split U19 *
| 20.10.2021 | Hajduk Split U19 | 3-1 | Shkendija'79 Youth | |
| 30.09.2021 | Shkendija'79 Youth | 0-2 | Hajduk Split U19 | |
APOEL FC Youth 1-2 Kairat Almaty Youth *
| 20.10.2021 | Kairat Almaty Youth | 1-0 | APOEL FC Youth | |
| 29.09.2021 | APOEL FC Youth | 1-1 | Kairat Almaty Youth | |
PAOK Youth 1-7 MSK Zilina Youth *
| 20.10.2021 | MSK Zilina Youth | 2-0 | PAOK Youth | |
| 29.09.2021 | PAOK Youth | 1-5 | MSK Zilina Youth | |
*MTK Budapest U19 6-4 Sparta Praha Youth
| 20.10.2021 | Sparta Praha Youth | 3-3 | MTK Budapest U19 | |
| 29.09.2021 | MTK Budapest U19 | 3-1 | Sparta Praha Youth | |
Pogon Sz. Youth 3-4 Depor La Coruña Yth *
| 20.10.2021 | Depor La Coruña Yth | 4-0 | Pogon Sz. Youth | |
| 29.09.2021 | Pogon Sz. Youth | 3-0 | Depor La Coruña Yth | |
*Rangers Youth 5-1 Hammarby IF Youth
| 20.10.2021 | Hammarby IF Youth | 1-2 | Rangers Youth | |
| 28.09.2021 | Rangers Youth | 3-0 | Hammarby IF Youth | |
Rosenborg Youth 3-14 Midtjylland Youth *
| 19.10.2021 | Midtjylland Youth | 10-1 | Rosenborg Youth | |
| 30.09.2021 | Rosenborg Youth | 2-4 | Midtjylland Youth | |
Zvijezda Bijeljina Youth 0-3 Trabzonspor Youth *
| 20.10.2021 | Trabzonspor Youth | 2-0 | Zvijezda Bijeljina Youth | |
| 29.09.2021 | Zvijezda Bijeljina Youth | 0-1 | Trabzonspor Youth | |
VMFD Zalgiris Youth 0-5 Maccabi Haifa Youth *
| 20.10.2021 | Maccabi Haifa Youth | 2-0 | VMFD Zalgiris Youth | |
| 28.09.2021 | VMFD Zalgiris Youth | 0-3 | Maccabi Haifa Youth | |