Angers SCO Youth 1-1 AZ Alkmaar Youth *
| 23.11.2021 | AZ Alkmaar Youth | 0-1/p.5-4 | Angers SCO Youth | |
| 03.11.2021 | Angers SCO Youth | 0-1 | AZ Alkmaar Youth | |
*Depor La Coruña Yth 5-4 Maccabi Haifa Youth
| 08.12.2021 | Maccabi Haifa Youth | 3-0 | Depor La Coruña Yth | |
| 03.11.2021 | Depor La Coruña Yth | 5-1 | Maccabi Haifa Youth | |
*Hajduk Split U19 4-1 Dinamo Minsk Youth
| 24.11.2021 | Dinamo Minsk Youth | 1-1 | Hajduk Split U19 | |
| 03.11.2021 | Hajduk Split U19 | 3-0 | Dinamo Minsk Youth | |
Crvena Zvezda Youth 1-6 Empoli Youth *
| 23.11.2021 | Empoli Youth | 5-0 | Crvena Zvezda Youth | |
| 03.11.2021 | Crvena Zvezda Youth | 1-1 | Empoli Youth | |
*MSK Zilina Youth 3-3 Kairat Almaty Youth
| 24.11.2021 | Kairat Almaty Youth | 1-0/p.0-3 | MSK Zilina Youth | |
| 03.11.2021 | MSK Zilina Youth | 3-2 | Kairat Almaty Youth | |
Trabzonspor Youth 2-10 Midtjylland Youth *
| 23.11.2021 | Midtjylland Youth | 5-0 | Trabzonspor Youth | |
| 02.11.2021 | Trabzonspor Youth | 2-5 | Midtjylland Youth | |
MTK Budapest U19 1-3 Racing Genk Youth *
| 23.11.2021 | Racing Genk Youth | 1-0 | MTK Budapest U19 | |
| 03.11.2021 | MTK Budapest U19 | 1-2 | Racing Genk Youth | |
Septemvri Youth 2-7 Rangers Youth *
| 07.12.2021 | Rangers Youth | 3-0 | Septemvri Youth | |
| 24.11.2021 | Septemvri Youth | 2-4 | Rangers Youth | |