VMFD Zalgiris Youth 2-5 AS Trenčín Youth *
| 05.10.2022 | AS Trenčín Youth | 4-0 | VMFD Zalgiris Youth | |
| 14.09.2022 | VMFD Zalgiris Youth | 2-1 | AS Trenčín Youth | |
*AZ Alkmaar Youth 6-1 Shamrock Rovers Yth
| 04.10.2022 | Shamrock Rovers Yth | 1-1 | AZ Alkmaar Youth | |
| 14.09.2022 | AZ Alkmaar Youth | 5-0 | Shamrock Rovers Yth | |
*FC Ashdod Youth 5-0 Borac B. Luka Youth
| 12.10.2022 | Borac B. Luka Youth | 0-3 | FC Ashdod Youth | |
| 14.09.2022 | FC Ashdod Youth | 2-0 | Borac B. Luka Youth | |
FC Astana Youth 2-4 Apolonia Fier Youth *
| 05.10.2022 | Apolonia Fier Youth | 3-1 | FC Astana Youth | |
| 15.09.2022 | FC Astana Youth | 1-1 | Apolonia Fier Youth | |
FK Csikszereda Youth 1-5 Galatasaray Youth *
| 05.10.2022 | Galatasaray Youth | 4-0 | FK Csikszereda Youth | |
| 14.09.2022 | FK Csikszereda Youth | 1-1 | Galatasaray Youth | |
*Hajduk Split U19 5-1 Gabala FC Youth
| 04.10.2022 | Gabala FC Youth | 1-2 | Hajduk Split U19 | |
| 12.09.2022 | Hajduk Split U19 | 3-0 | Gabala FC Youth | |
Molde Youth 2-2 Hibernian Youth *
| 05.10.2022 | Hibernian Youth | 2-1/p.5-4 | Molde Youth | |
| 14.09.2022 | Molde Youth | 1-0 | Hibernian Youth | |
*MTK Budapest U19 4-0 FK Jelgava Youth
| 05.10.2022 | FK Jelgava Youth | 0-1 | MTK Budapest U19 | |
| 14.09.2022 | MTK Budapest U19 | 3-0 | FK Jelgava Youth | |
*Crvena Zvezda Youth 3-1 Omonia Nic. Youth
| 05.10.2022 | Omonia Nic. Youth | 1-2 | Crvena Zvezda Youth | |
| 14.09.2022 | Crvena Zvezda Youth | 1-0 | Omonia Nic. Youth | |
*Panathinaikos Youth 10-2 Slavia Sofia Youth
| 05.10.2022 | Slavia Sofia Youth | 2-2 | Panathinaikos Youth | |
| 14.09.2022 | Panathinaikos Youth | 8-0 | Slavia Sofia Youth | |
*Coleraine FC Youth 5-4 Pobeda Prilep Youth
| 05.10.2022 | Pobeda Prilep Youth | 2-2 | Coleraine FC Youth | |
| 28.09.2022 | Coleraine FC Youth | 3-2 | Pobeda Prilep Youth | |
*FC Nantes Youth 5-0 Pyunik FC Youth
| 05.10.2022 | Pyunik FC Youth | 0-3 | FC Nantes Youth | |
| 14.09.2022 | FC Nantes Youth | 2-0 | Pyunik FC Youth | |
*AIK Youth 8-2 RFCU Luxemburg Youth
| 05.10.2022 | RFCU Luxemburg Youth | 2-3 | AIK Youth | |
| 14.09.2022 | AIK Youth | 5-0 | RFCU Luxemburg Youth | |
*Racing Genk Youth 5-4 Slavia Praha Youth
| 05.10.2022 | Slavia Praha Youth | 2-4 | Racing Genk Youth | |
| 14.09.2022 | Racing Genk Youth | 1-2 | Slavia Praha Youth | |
*Young Boys Youth 5-2 Domžale Youth
| 05.10.2022 | Domžale Youth | 2-2 | Young Boys Youth | |
| 14.09.2022 | Young Boys Youth | 3-0 | Domžale Youth | |
*Rukh Lviv Youth 1-0 Zaglebie L. Youth
| 05.10.2022 | Zaglebie L. Youth | 0-0 | Rukh Lviv Youth | |
| 14.09.2022 | Rukh Lviv Youth | 1-0 | Zaglebie L. Youth | |