*Arsenal LFC (W) 3-2 AFC Ajax (W)
| 28.09.2022 | AFC Ajax (W) | 0-1 | Arsenal LFC (W) | |
| 20.09.2022 | Arsenal LFC (W) | 2-2 | AFC Ajax (W) | |
Real Sociedad (W) 1-4 Bayern München (W) *
| 29.09.2022 | Bayern München (W) | 3-1 | Real Sociedad (W) | |
| 20.09.2022 | Real Sociedad (W) | 0-1 | Bayern München (W) | |
SFK 2000 Sarajevo (W) 0-10 FC Zürich (W) *
| 28.09.2022 | FC Zürich (W) | 3-0 | SFK 2000 Sarajevo (W) | |
| 21.09.2022 | SFK 2000 Sarajevo (W) | 0-7 | FC Zürich (W) | |
KuPS Kuopio (W) 2-3 FSK St. Pölten (W) *
| 28.09.2022 | FSK St. Pölten (W) | 2-2 AET | KuPS Kuopio (W) | |
| 21.09.2022 | KuPS Kuopio (W) | 0-1 | FSK St. Pölten (W) | |
HB Køge (W) 1-3 Juventus (W) *
| 28.09.2022 | Juventus (W) | 2-0 | HB Køge (W) | |
| 20.09.2022 | HB Køge (W) | 1-1 | Juventus (W) | |
*Paris SG (W) 4-1 BK Hacken FF (W)
| 28.09.2022 | BK Hacken FF (W) | 0-2 | Paris SG (W) | |
| 21.09.2022 | Paris SG (W) | 2-1 | BK Hacken FF (W) | |
Rosenborg (W) 1-5 Real Madrid (W) *
| 28.09.2022 | Real Madrid (W) | 2-1 | Rosenborg (W) | |
| 21.09.2022 | Rosenborg (W) | 0-3 | Real Madrid (W) | |
SK Brann (W) 2-4 Rosengård (W) *
| 28.09.2022 | Rosengård (W) | 3-1 | SK Brann (W) | |
| 21.09.2022 | SK Brann (W) | 1-1 | Rosengård (W) | |
Rangers LFC (W) 3-5 SL Benfica (W) *
| 28.09.2022 | SL Benfica (W) | 2-1 AET | Rangers LFC (W) | |
| 20.09.2022 | Rangers LFC (W) | 2-3 | SL Benfica (W) | |
Valur (W) 0-1 Slavia Praha (W) *
| 28.09.2022 | Slavia Praha (W) | 0-0 | Valur (W) | |
| 21.09.2022 | Valur (W) | 0-1 | Slavia Praha (W) | |
Sparta Praha (W) 2-6 AS Roma (W) *
| 29.09.2022 | AS Roma (W) | 4-1 | Sparta Praha (W) | |
| 21.09.2022 | Sparta Praha (W) | 1-2 | AS Roma (W) | |
Vorskla (W) 2-3 Vllaznia Shkodër (W) *
| 28.09.2022 | Vllaznia Shkodër (W) | 2-1 | Vorskla (W) | |
| 21.09.2022 | Vorskla (W) | 1-1 | Vllaznia Shkodër (W) | |