Dinamo Tirana 1-2 Partizani Tirana *
| 10.02.2022 | Partizani Tirana | 1-0 | Dinamo Tirana | |
| 27.01.2022 | Dinamo Tirana | 1-1 | Partizani Tirana | |
Egnatia Rrogozhinë 1-1 KF Laci *
| 10.02.2022 | KF Laci | 0-0/p.3-2 | Egnatia Rrogozhinë | |
| 26.01.2022 | Egnatia Rrogozhinë | 1-1 | KF Laci | |
Flamurtari Vlore 1-3 Vllaznia Shkodër *
| 10.02.2022 | Vllaznia Shkodër | 1-0 | Flamurtari Vlore | |
| 26.01.2022 | Flamurtari Vlore | 1-2 | Vllaznia Shkodër | |
Skenderbeu 0-2 KF Teuta Durres *
| 09.02.2022 | KF Teuta Durres | 1-0 | Skenderbeu | |
| 27.01.2022 | Skenderbeu | 0-1 | KF Teuta Durres | |