Beselidhja Lezhe 1-2 Apolonia Fier *
| 12.10.2022 | Apolonia Fier | 1-1 | Beselidhja Lezhe | |
| 25.09.2022 | Beselidhja Lezhe | 0-1 | Apolonia Fier | |
Butrinti Sarandë 0-4 Dinamo Tirana *
| 11.10.2022 | Dinamo Tirana | 3-0 W.O. | Butrinti Sarandë | |
| 28.09.2022 | Butrinti Sarandë | 0-1 | Dinamo Tirana | |
Shkumbini 0-6 Egnatia Rrogozhinë *
| 12.10.2022 | Egnatia Rrogozhinë | 3-0 | Shkumbini | |
| 28.09.2022 | Shkumbini | 0-3 | Egnatia Rrogozhinë | |
*KS Kastrioti 1-0 FK Vora
| 12.10.2022 | FK Vora | 0-0 | KS Kastrioti | |
| 26.09.2022 | KS Kastrioti | 1-0 | FK Vora | |
Flamurtari Vlore 2-4 Vllaznia Shkodër *
| 12.10.2022 | Vllaznia Shkodër | 3-0 AET | Flamurtari Vlore | |
| 26.09.2022 | Flamurtari Vlore | 2-1 | Vllaznia Shkodër | |
Devolli Bilisht 0-7 KF Laci *
| 11.10.2022 | KF Laci | 5-0 | Devolli Bilisht | |
| 26.09.2022 | Devolli Bilisht | 0-2 | KF Laci | |
KF Luzi 2008 0-2 KF Teuta Durres *
| 11.10.2022 | KF Teuta Durres | 2-0 | KF Luzi 2008 | |
| 26.09.2022 | KF Luzi 2008 | 0-0 | KF Teuta Durres | |
Besa Kavaje 1-4 Korabi Peshkopi *
| 12.10.2022 | Korabi Peshkopi | 3-0 | Besa Kavaje | |
| 26.09.2022 | Besa Kavaje | 1-1 | Korabi Peshkopi | |
KS Burreli 2-5 Tomori Berat *
| 12.10.2022 | Tomori Berat | 4-0 AET | KS Burreli | |
| 28.09.2022 | KS Burreli | 2-1 | Tomori Berat | |
KS Pogradeci 1-10 Bylis Ballsh *
| 11.10.2022 | Bylis Ballsh | 7-1 | KS Pogradeci | |
| 26.09.2022 | KS Pogradeci | 0-3 | Bylis Ballsh | |
Labëria FC 0-5 FK Kukesi *
| 12.10.2022 | FK Kukesi | 2-0 | Labëria FC | |
| 26.09.2022 | Labëria FC | 0-3 | FK Kukesi | |
*Partizani Tirana 2-0 KF Oriku
| 12.10.2022 | KF Oriku | 0-2 | Partizani Tirana | |
| 28.09.2022 | Partizani Tirana | 0-0 | KF Oriku | |
KF Maliqi 1-8 Skenderbeu *
| 12.10.2022 | Skenderbeu | 3-0 | KF Maliqi | |
| 26.09.2022 | KF Maliqi | 1-5 | Skenderbeu | |
*KS Lushnja 3-3 Tërbuni Pukë
| 11.10.2022 | Tërbuni Pukë | 3-1 | KS Lushnja | |
| 28.09.2022 | KS Lushnja | 2-0 | Tërbuni Pukë | |
Turbina Cërrik 1-6 Erzeni Shijak *
| 12.10.2022 | Erzeni Shijak | 4-0 | Turbina Cërrik | |
| 26.09.2022 | Turbina Cërrik | 1-2 | Erzeni Shijak | |
Veleciku Koplik 2-5 KF Tirana *
| 12.10.2022 | KF Tirana | 2-2 | Veleciku Koplik | |
| 28.09.2022 | Veleciku Koplik | 0-3 | KF Tirana | |