Blooming 2-2 Oriente Petrolero *
| 21.06.2010 | Oriente Petrolero | 0-1 | Blooming | |
| 17.06.2010 | Blooming | 1-2 | Oriente Petrolero | |
*Jorge Wilstermann 4-1 Club Aurora
| 20.06.2010 | Club Aurora | 1-1 | Jorge Wilstermann | |
| 17.06.2010 | Jorge Wilstermann | 3-0 | Club Aurora | |
*CD San José 7-4 La Paz FC
| 19.06.2010 | La Paz FC | 1-4 | CD San José | |
| 16.06.2010 | CD San José | 3-3 | La Paz FC | |
CD Guabirá 1-2 Real Mamoré *
| 20.06.2010 | Real Mamoré | 0-1 | CD Guabirá | |
| 16.06.2010 | CD Guabirá | 0-2 | Real Mamoré | |
*Bolívar 2-2 The Strongest
| 20.06.2010 | The Strongest | 2-0/p.3-4 | Bolívar | |
| 18.06.2010 | Bolívar | 2-0 | The Strongest | |
Real Potosí 3-2 Universitario Sucre
| 21.06.2010 | Universitario Sucre | 2-0 | Real Potosí | |
| 17.06.2010 | Real Potosí | 3-0 | Universitario Sucre | |