Municipal Tiquipaya 3-5 CD FATIC *
| 28.11.2020 | CD FATIC | 2-1 | Municipal Tiquipaya | |
| 25.11.2020 | Municipal Tiquipaya | 2-3 | CD FATIC | |
*Chaco Petrolero 2-3 Cochabamba FC
| 28.11.2020 | Cochabamba FC | 3-0/p.2-4 | Chaco Petrolero | |
| 25.11.2020 | Chaco Petrolero | 2-0 | Cochabamba FC | |
Deportivo Kivón 3-8 CD Torre Fuerte *
| 28.11.2020 | CD Torre Fuerte | 1-1 | Deportivo Kivón | |
| 26.11.2020 | Deportivo Kivón | 2-7 | CD Torre Fuerte | |
Fancesa 4-4 Real Tomayapo *
| 29.11.2020 | Real Tomayapo | 3-1/p.4-2 | Fancesa | |
| 25.11.2020 | Fancesa | 3-1 | Real Tomayapo | |
Quebracho 4-5 Independiente Petrolero *
| 29.11.2020 | Independiente Petrolero | 3-1/p.5-4 | Quebracho | |
| 25.11.2020 | Quebracho | 3-2 | Independiente Petrolero | |
Rosario Central (BOL) 1-1 Oruro Royal *
| 28.11.2020 | Oruro Royal | 0-0/p.3-1 | Rosario Central (BOL) | |
| 25.11.2020 | Rosario Central (BOL) | 1-1 | Oruro Royal | |
Satélite Norte 2-5 Libertad Beni *
| 29.11.2020 | Libertad Beni | 4-1 | Satélite Norte | |
| 25.11.2020 | Satélite Norte | 1-1 | Libertad Beni | |
*EM Huanuni 5-7 Stormers San Lorenzo
| 28.11.2020 | Stormers San Lorenzo | 6-2/p.2-3 | EM Huanuni | |
| 25.11.2020 | EM Huanuni | 3-1 | Stormers San Lorenzo | |
Mariscal Sucre 2-4 Vaca Díez *
| 29.11.2020 | Vaca Díez | 3-0/p.4-2 | Mariscal Sucre | |
| 26.11.2020 | Mariscal Sucre | 2-1 | Vaca Díez | |