Chaco Petrolero 0-7 Independiente Petrolero *
| 05.12.2020 | Independiente Petrolero | 5-0 | Chaco Petrolero | |
| 02.12.2020 | Chaco Petrolero | 0-2 | Independiente Petrolero | |
*Cochabamba FC 2-2 Stormers San Lorenzo
| 05.12.2020 | Stormers San Lorenzo | 1-1/p.3-5 | Cochabamba FC | |
| 02.12.2020 | Cochabamba FC | 1-1 | Stormers San Lorenzo | |
EM Huanuni 2-6 Real Tomayapo *
| 05.12.2020 | Real Tomayapo | 5-0/p.4-1 | EM Huanuni | |
| 02.12.2020 | EM Huanuni | 2-1 | Real Tomayapo | |
CD Torre Fuerte 2-3 Libertad Beni *
| 05.12.2020 | Libertad Beni | 0-1/p.5-4 | CD Torre Fuerte | |
| 02.12.2020 | CD Torre Fuerte | 1-3 | Libertad Beni | |
Oruro Royal 4-6 Vaca Díez *
| 05.12.2020 | Vaca Díez | 2-2 | Oruro Royal | |
| 02.12.2020 | Oruro Royal | 2-4 | Vaca Díez | |