Avai FC/SC 1-1 Brusque FC/SC *
| 19.03.2022 | Brusque FC/SC | 0-0 | Avai FC/SC | |
| 13.03.2022 | Avai FC/SC | 1-1 | Brusque FC/SC | |
Chapecoense/SC 2-2 Concórdia AC/SC *
| 20.03.2022 | Concórdia AC/SC | 1-1 | Chapecoense/SC | |
| 13.03.2022 | Chapecoense/SC | 1-1 | Concórdia AC/SC | |
*Figueirense/SC 1-0 Hercílio Luz/SC
| 20.03.2022 | Hercílio Luz/SC | 0-0 | Figueirense/SC | |
| 12.03.2022 | Figueirense/SC | 1-0 | Hercílio Luz/SC | |
Marcilio Dias/SC 3-4 Camboriú/SC *
| 19.03.2022 | Camboriú/SC | 3-2 | Marcilio Dias/SC | |
| 12.03.2022 | Marcilio Dias/SC | 1-1 | Camboriú/SC | |