Atlético/GO 2-5 Brasiliense/DF *
| 07.02.2021 | Brasiliense/DF | 3-1 | Atlético/GO | |
| 04.02.2021 | Atlético/GO | 1-2 | Brasiliense/DF | |
Cuiabá/MT 1-3 Vila Nova/GO *
| 08.02.2021 | Vila Nova/GO | 3-0 | Cuiabá/MT | |
| 06.02.2021 | Cuiabá/MT | 1-0 | Vila Nova/GO | |
*Manaus FC/AM 3-2 Paysandu/PA
| 07.02.2021 | Paysandu/PA | 1-2 | Manaus FC/AM | |
| 03.02.2021 | Manaus FC/AM | 1-1 | Paysandu/PA | |
*Remo/PA 3-3 Independente/PA
| 07.02.2021 | Independente/PA | 3-1/p.0-3 | Remo/PA | |
| 03.02.2021 | Remo/PA | 2-0 | Independente/PA | |