*Athletico/PR 4-3 Atlético/GO
| 05.08.2021 | Atlético/GO | 2-2 | Athletico/PR | |
| 28.07.2021 | Athletico/PR | 2-1 | Atlético/GO | |
*Atlético Mineiro/MG 3-2 Bahia/BA
| 05.08.2021 | Bahia/BA | 2-1 | Atlético Mineiro/MG | |
| 29.07.2021 | Atlético Mineiro/MG | 2-0 | Bahia/BA | |
*Flamengo/RJ 7-0 ABC Natal/RN
| 06.08.2021 | ABC Natal/RN | 0-1 | Flamengo/RJ | |
| 30.07.2021 | Flamengo/RJ | 6-0 | ABC Natal/RN | |
Criciúma/SC 2-4 Fluminense/RJ *
| 31.07.2021 | Fluminense/RJ | 3-0 | Criciúma/SC | |
| 28.07.2021 | Criciúma/SC | 2-1 | Fluminense/RJ | |
*Fortaleza/CE 3-1 CRB/AL
| 04.08.2021 | CRB/AL | 0-1 | Fortaleza/CE | |
| 29.07.2021 | Fortaleza/CE | 2-1 | CRB/AL | |
*Santos/SP 4-2 Juazeirense/BA
| 06.08.2021 | Juazeirense/BA | 2-0 | Santos/SP | |
| 29.07.2021 | Santos/SP | 4-0 | Juazeirense/BA | |
*São Paulo/SP 4-1 Vasco da Gama/RJ
| 05.08.2021 | Vasco da Gama/RJ | 1-2 | São Paulo/SP | |
| 29.07.2021 | São Paulo/SP | 2-0 | Vasco da Gama/RJ | |
Vitória/BA 0-4 Grêmio/RS *
| 04.08.2021 | Grêmio/RS | 1-0 | Vitória/BA | |
| 28.07.2021 | Vitória/BA | 0-3 | Grêmio/RS | |