CSA/AL 0-5 América Mineiro/MG *
| 11.05.2022 | América Mineiro/MG | 2-0 | CSA/AL | |
| 20.04.2022 | CSA/AL | 0-3 | América Mineiro/MG | |
Tocantinópolis/TO 2-9 Athletico/PR *
| 11.05.2022 | Athletico/PR | 4-0 | Tocantinópolis/TO | |
| 21.04.2022 | Tocantinópolis/TO | 2-5 | Athletico/PR | |
*Atlético Mineiro/MG 4-0 Brasiliense/DF
| 23.05.2022 | Brasiliense/DF | 0-1 | Atlético Mineiro/MG | |
| 21.04.2022 | Atlético Mineiro/MG | 3-0 | Brasiliense/DF | |
*Atlético/GO 1-1 Cuiabá/MT
| 12.05.2022 | Cuiabá/MT | 0-0/p.3-5 | Atlético/GO | |
| 22.04.2022 | Atlético/GO | 1-1 | Cuiabá/MT | |
*Bahia/BA 1-1 Azuriz FC/PR
| 11.05.2022 | Azuriz FC/PR | 1-1/p.3-4 | Bahia/BA | |
| 20.04.2022 | Bahia/BA | 0-0 | Azuriz FC/PR | |
Ceilândia/DF 0-6 Botafogo/RJ *
| 13.05.2022 | Botafogo/RJ | 3-0 | Ceilândia/DF | |
| 21.04.2022 | Ceilândia/DF | 0-3 | Botafogo/RJ | |
Tombense FC/MG 0-4 Ceará SC/CE *
| 12.05.2022 | Ceará SC/CE | 2-0 | Tombense FC/MG | |
| 21.04.2022 | Tombense FC/MG | 0-2 | Ceará SC/CE | |
Portuguesa/RJ 1-3 Corinthians/SP *
| 12.05.2022 | Corinthians/SP | 2-0 | Portuguesa/RJ | |
| 21.04.2022 | Portuguesa/RJ | 1-1 | Corinthians/SP | |
Coritiba/PR 1-3 Santos/SP *
| 13.05.2022 | Santos/SP | 3-0 | Coritiba/PR | |
| 21.04.2022 | Coritiba/PR | 1-0 | Santos/SP | |
Remo/PA 2-2 Cruzeiro/MG *
| 13.05.2022 | Cruzeiro/MG | 1-0/p.5-4 | Remo/PA | |
| 20.04.2022 | Remo/PA | 2-1 | Cruzeiro/MG | |
Altos/PI 1-4 Flamengo/RJ *
| 12.05.2022 | Flamengo/RJ | 2-0 | Altos/PI | |
| 01.05.2022 | Altos/PI | 1-2 | Flamengo/RJ | |
*Fortaleza/CE 4-0 Vitória/BA
| 13.05.2022 | Vitória/BA | 0-1 | Fortaleza/CE | |
| 21.04.2022 | Fortaleza/CE | 3-0 | Vitória/BA | |
*Goiás/GO 2-2 RB Bragantino/SP
| 01.06.2022 | RB Bragantino/SP | 0-1/p.8-9 | Goiás/GO | |
| 21.04.2022 | Goiás/GO | 1-2 | RB Bragantino/SP | |
*Palmeiras/SP 4-2 Juazeirense/BA
| 12.05.2022 | Juazeirense/BA | 1-2 | Palmeiras/SP | |
| 01.05.2022 | Palmeiras/SP | 2-1 | Juazeirense/BA | |
Juventude/RS 2-4 São Paulo/SP *
| 13.05.2022 | São Paulo/SP | 2-0 | Juventude/RS | |
| 21.04.2022 | Juventude/RS | 2-2 | São Paulo/SP | |
*Fluminense/RJ 5-2 Vila Nova/GO
| 12.05.2022 | Vila Nova/GO | 0-2 | Fluminense/RJ | |
| 20.04.2022 | Fluminense/RJ | 3-2 | Vila Nova/GO | |