*Globo FC/RN 3-2 ABC Natal/RN
| 12.12.2020 | ABC Natal/RN | 1-1 | Globo FC/RN | |
| 06.12.2020 | Globo FC/RN | 2-1 | ABC Natal/RN | |
Alagoinhas Atlético/BA 3-4 Goiânia/GO *
| 12.12.2020 | Goiânia/GO | 3-2 | Alagoinhas Atlético/BA | |
| 05.12.2020 | Alagoinhas Atlético/BA | 1-1 | Goiânia/GO | |
Rio Branco/AC 1-5 Altos/PI *
| 13.12.2020 | Altos/PI | 3-1 | Rio Branco/AC | |
| 07.12.2020 | Rio Branco/AC | 0-2 | Altos/PI | |
Coruripe/AL 1-5 América/RN *
| 13.12.2020 | América/RN | 5-0 | Coruripe/AL | |
| 06.12.2020 | Coruripe/AL | 1-0 | América/RN | |
*Juventude/MA 2-2 Bragantino/PA
| 12.12.2020 | Bragantino/PA | 1-1/p.3-4 | Juventude/MA | |
| 05.12.2020 | Juventude/MA | 1-1 | Bragantino/PA | |
Real Noroeste/ES 1-4 Brasiliense/DF *
| 12.12.2020 | Brasiliense/DF | 3-0 | Real Noroeste/ES | |
| 06.12.2020 | Real Noroeste/ES | 1-1 | Brasiliense/DF | |
Cabofriense/RJ 1-3 São Luiz/RS *
| 13.12.2020 | São Luiz/RS | 2-0 | Cabofriense/RJ | |
| 06.12.2020 | Cabofriense/RJ | 1-1 | São Luiz/RS | |
Cascavel/PR 1-3 Novorizontino/SP *
| 12.12.2020 | Novorizontino/SP | 3-0 | Cascavel/PR | |
| 05.12.2020 | Cascavel/PR | 1-0 | Novorizontino/SP | |
Moto Clube/MA 3-3 Fast Clube/AM *
| 13.12.2020 | Fast Clube/AM | 1-1/p.6-5 | Moto Clube/MA | |
| 06.12.2020 | Moto Clube/MA | 2-2 | Fast Clube/AM | |
*Floresta/CE 4-3 Itabaiana/SE
| 12.12.2020 | Itabaiana/SE | 2-2 | Floresta/CE | |
| 05.12.2020 | Floresta/CE | 2-1 | Itabaiana/SE | |
*Goianésia/GO 4-3 Gama/DF
| 13.12.2020 | Gama/DF | 1-2 | Goianésia/GO | |
| 06.12.2020 | Goianésia/GO | 2-2 | Gama/DF | |
*Marcilio Dias/SC 2-1 Ferroviária/SP
| 13.12.2020 | Ferroviária/SP | 1-2 | Marcilio Dias/SC | |
| 05.12.2020 | Marcilio Dias/SC | 0-0 | Ferroviária/SP | |
Caxias/RS 1-1 Mirassol/SP *
| 13.12.2020 | Mirassol/SP | 1-0/p.3-0 | Caxias/RS | |
| 05.12.2020 | Caxias/RS | 1-0 | Mirassol/SP | |
Vitoria Conquista/BA 4-7 Salgueiro/PE *
| 13.12.2020 | Salgueiro/PE | 4-0 | Vitoria Conquista/BA | |
| 06.12.2020 | Vitoria Conquista/BA | 4-3 | Salgueiro/PE | |
Tupynambás/MG 1-5 Aparecidense/GO *
| 13.12.2020 | Aparecidense/GO | 4-0 | Tupynambás/MG | |
| 06.12.2020 | Tupynambás/MG | 1-1 | Aparecidense/GO | |