Real Ariquemes/RO 1-5 Brasiliense/DF *
| 30.05.2021 | Brasiliense/DF | 3-1 | Real Ariquemes/RO | |
| 26.05.2021 | Real Ariquemes/RO | 0-2 | Brasiliense/DF | |
Santana EC/AP 1-5 GAS/RR *
| 30.05.2021 | GAS/RR | 3-0 | Santana EC/AP | |
| 26.05.2021 | Santana EC/AP | 1-2 | GAS/RR | |
*Tocantinópolis/TO 3-3 Picos/PI
| 30.05.2021 | Picos/PI | 3-1/p.1-4 | Tocantinópolis/TO | |
| 26.05.2021 | Tocantinópolis/TO | 2-0 | Picos/PI | |
Aquidauanense/MS 1-6 Rio Branco/ES *
| 30.05.2021 | Rio Branco/ES | 2-0 | Aquidauanense/MS | |
| 26.05.2021 | Aquidauanense/MS | 1-4 | Rio Branco/ES | |