Atlético-New Oil 1-2 Aigle Noir *
| 20.03.2022 | Aigle Noir | 1-1 | Atlético-New Oil | |
| 05.03.2022 | Atlético-New Oil | 0-1 | Aigle Noir | |
*Bujumbura City 3-2 Vital'O FC
| 20.03.2022 | Vital'O FC | 1-3 | Bujumbura City | |
| 06.03.2022 | Bujumbura City | 0-1 | Vital'O FC | |
Kayanza United 3-3 Bumamuru FC *
| 20.03.2022 | Bumamuru FC | 3-2/p.4-2 | Kayanza United | |
| 05.03.2022 | Kayanza United | 1-0 | Bumamuru FC | |
Le Messager Ngozi 3-3 BS Dynamic *
| 19.03.2022 | BS Dynamic | 2-1/p.9-8 | Le Messager Ngozi | |
| 06.03.2022 | Le Messager Ngozi | 2-1 | BS Dynamic | |
Olympique Star 4-4 Musongati FC *
| 20.03.2022 | Musongati FC | 3-1/p.4-3 | Olympique Star | |
| 06.03.2022 | Olympique Star | 3-1 | Musongati FC | |
Royal FC (BDI) 1-2 Les Crocos FC *
| 20.03.2022 | Les Crocos FC | 1-1 | Royal FC (BDI) | |
| 06.03.2022 | Royal FC (BDI) | 0-1 | Les Crocos FC | |
*Rukinzo FC 4-0 Tigre Noir FC
| 19.03.2022 | Tigre Noir FC | 0-2 | Rukinzo FC | |
| 06.03.2022 | Rukinzo FC | 2-0 | Tigre Noir FC | |
Top Junior FC 0-5 Flambeau du Centre *
| 19.03.2022 | Flambeau du Centre | 3-0 | Top Junior FC | |
| 06.03.2022 | Top Junior FC | 0-2 | Flambeau du Centre | |