Apollon Limassol 1-2 AEL Limassol *
| 02.03.2022 | AEL Limassol | 2-0 AET | Apollon Limassol | |
| 26.01.2022 | Apollon Limassol | 1-0 | AEL Limassol | |
Pafos FC 1-3 Anorthosis FC *
| 03.02.2022 | Anorthosis FC | 0-0 | Pafos FC | |
| 19.01.2022 | Pafos FC | 1-3 | Anorthosis FC | |
Ermis Aradippou 1-6 EN Paralimni *
| 19.01.2022 | EN Paralimni | 5-0 | Ermis Aradippou | |
| 12.01.2022 | Ermis Aradippou | 1-1 | EN Paralimni | |
*Ethnikos Achnas 3-1 Doxa Katokopia
| 03.02.2022 | Doxa Katokopia | 0-0 | Ethnikos Achnas | |
| 26.01.2022 | Ethnikos Achnas | 3-1 | Doxa Katokopia | |
*APOEL FC 6-1 Olympiakos Nicosia
| 02.02.2022 | Olympiakos Nicosia | 0-4 | APOEL FC | |
| 19.01.2022 | APOEL FC | 2-1 | Olympiakos Nicosia | |
*Onisilos Sotiras* 5-3 Karmiotissa Polemidion
| 19.01.2022 | Karmiotissa Polemidion | 0-1 | Onisilos Sotiras* | |
| 12.01.2022 | Onisilos Sotiras* | 4-3 | Karmiotissa Polemidion | |
*AEK Larnaca 3-3 PAEEK Kyrenia
| 02.03.2022 | PAEEK Kyrenia | 2-2 | AEK Larnaca | |
| 18.01.2022 | AEK Larnaca | 1-1 | PAEEK Kyrenia | |
PO Xylotymbou 1-7 Omonia Nicosia *
| 01.02.2022 | Omonia Nicosia | 2-1 | PO Xylotymbou | |
| 20.01.2022 | PO Xylotymbou | 0-5 | Omonia Nicosia | |