CD Aspirante 0-1 Platense (SLV) *
| 10.01.2021 | Platense (SLV) | 0-0 | CD Aspirante | |
| 03.01.2021 | CD Aspirante | 0-1 | Platense (SLV) | |
CD Titán 3-4 AD Destroyer *
| 10.01.2021 | AD Destroyer | 1-1 | CD Titán | |
| 03.01.2021 | CD Titán | 2-3 | AD Destroyer | |
Fuerte San Francisco 1-2 CD Cacahuatique *
| 10.01.2021 | CD Cacahuatique | 2-0 | Fuerte San Francisco | |
| 03.01.2021 | Fuerte San Francisco | 1-0 | CD Cacahuatique | |
*Marte Soyapango 3-3 San Pablo Tacachico
| 10.01.2021 | San Pablo Tacachico | 2-1/p.4-5 | Marte Soyapango | |
| 03.01.2021 | Marte Soyapango | 2-1 | San Pablo Tacachico | |