*AD Ínter Sivar 1-1 AD Destroyer
| 05.12.2021 | AD Destroyer | 1-1/p.3-5 | AD Ínter Sivar | |
| 28.11.2021 | AD Ínter Sivar | 0-0 | AD Destroyer | |
*AD Municipal de Juayúa 3-1 CD San Pablo Municipal
| 05.12.2021 | CD San Pablo Municipal | 1-1 | AD Municipal de Juayúa | |
| 28.11.2021 | AD Municipal de Juayúa | 2-0 | CD San Pablo Municipal | |
CD Topiltzin 0-3 CD Cacahuatique *
| 05.12.2021 | CD Cacahuatique | 2-0 | CD Topiltzin | |
| 28.11.2021 | CD Topiltzin | 0-1 | CD Cacahuatique | |
Corinto FC 1-3 Marte Soyapango *
| 05.12.2021 | Marte Soyapango | 2-0 | Corinto FC | |
| 27.11.2021 | Corinto FC | 1-1 | Marte Soyapango | |