*AE Larisa 3-2 SKODA Xanthi
| 10.01.2018 | SKODA Xanthi | 2-0 | AE Larisa | |
| 21.12.2017 | AE Larisa | 3-0 | SKODA Xanthi | |
Asteras Tripoli 0-2 Atromitos FC *
| 11.01.2018 | Atromitos FC | 1-0 | Asteras Tripoli | |
| 20.12.2017 | Asteras Tripoli | 0-1 | Atromitos FC | |
*Panionios GSS 3-0 OFI Creta
| 09.01.2018 | OFI Creta | 0-1 | Panionios GSS | |
| 21.12.2017 | Panionios GSS | 2-0 | OFI Creta | |
AO Platanias 0-4 Olympiakos Pireus *
| 10.01.2018 | Olympiakos Pireus | 2-0 | AO Platanias | |
| 20.12.2017 | AO Platanias | 0-2 | Olympiakos Pireus | |
*Lamia FC 4-2 Panathinaikos
| 10.01.2018 | Panathinaikos | 1-0 | Lamia FC | |
| 21.12.2017 | Lamia FC | 4-1 | Panathinaikos | |
Panetolikos 0-5 AEK Athens *
| 09.01.2018 | AEK Athens | 1-0 | Panetolikos | |
| 20.12.2017 | Panetolikos | 0-4 | AEK Athens | |
AO Trikala 2-7 PAOK Salonica *
| 09.01.2018 | PAOK Salonica | 2-1 | AO Trikala | |
| 19.12.2017 | AO Trikala | 1-5 | PAOK Salonica | |
Levadiakos 1-4 PAS Giannina *
| 10.01.2018 | PAS Giannina | 4-0 | Levadiakos | |
| 21.12.2017 | Levadiakos | 1-0 | PAS Giannina | |