Aris Salonica 0-1 Lamia FC *
| 26.01.2022 | Lamia FC | 1-0 AET | Aris Salonica | |
| 20.01.2022 | Aris Salonica | 0-0 | Lamia FC | |
*Panathinaikos 5-0 Anagennisi Karditsa
| 09.02.2022 | Anagennisi Karditsa | 0-1 | Panathinaikos | |
| 19.01.2022 | Panathinaikos | 4-0 | Anagennisi Karditsa | |
Panetolikos 3-4 Olympiakos Pireus *
| 09.02.2022 | Olympiakos Pireus | 3-1 AET | Panetolikos | |
| 19.01.2022 | Panetolikos | 2-1 | Olympiakos Pireus | |
*PAOK Salonica 2-1 AEK Athens
| 09.02.2022 | AEK Athens | 1-2 | PAOK Salonica | |
| 19.01.2022 | PAOK Salonica | 0-0 | AEK Athens | |