Cremonese Youth 2-2 Frosinone Youth *
| 07.05.2022 | Frosinone Youth | 0-1 | Cremonese Youth | |
| 30.04.2022 | Cremonese Youth | 1-2 | Frosinone Youth | |
Lazio Youth 3-4 Brescia Youth *
| 07.05.2022 | Brescia Youth | 1-2 | Lazio Youth | |
| 30.04.2022 | Lazio Youth | 1-3 | Brescia Youth | |
*Monza Youth 3-0 AC Pisa Youth
| 07.05.2022 | AC Pisa Youth | 0-1 | Monza Youth | |
| 30.04.2022 | Monza Youth | 2-0 | AC Pisa Youth | |
Perugia Youth 3-10 Parma Youth *
| 07.05.2022 | Parma Youth | 7-0 | Perugia Youth | |
| 30.04.2022 | Perugia Youth | 3-3 | Parma Youth | |