*Empoli Ladies (W) 2-2 Fiorentina (W)
| 12.02.2022 | Fiorentina (W) | 2-2 | Empoli Ladies (W) | |
| 29.01.2022 | Empoli Ladies (W) | 0-0 | Fiorentina (W) | |
FC Como (W) 1-5 AS Roma (W) *
| 13.02.2022 | AS Roma (W) | 2-1 | FC Como (W) | |
| 29.01.2022 | FC Como (W) | 0-3 | AS Roma (W) | |
Inter Milan (W) 1-2 Juventus (W) *
| 13.02.2022 | Juventus (W) | 1-0 | Inter Milan (W) | |
| 30.01.2022 | Inter Milan (W) | 1-1 | Juventus (W) | |
Sampdoria (W) 2-8 ACF Milan (W) *
| 12.02.2022 | ACF Milan (W) | 4-1 | Sampdoria (W) | |
| 30.01.2022 | Sampdoria (W) | 1-4 | ACF Milan (W) | |