*Cerezo Osaka 4-1 Gamba Osaka
| 05.09.2021 | Gamba Osaka | 0-4 | Cerezo Osaka | |
| 01.09.2021 | Cerezo Osaka | 0-1 | Gamba Osaka | |
Consadole Sapporo 2-3 FC Tokyo *
| 05.09.2021 | FC Tokyo | 2-0 | Consadole Sapporo | |
| 01.09.2021 | Consadole Sapporo | 2-1 | FC Tokyo | |
*Nagoya Grampus 4-0 Kashima Antlers
| 05.09.2021 | Kashima Antlers | 0-2 | Nagoya Grampus | |
| 01.09.2021 | Nagoya Grampus | 2-0 | Kashima Antlers | |
*Urawa Red Diamonds 4-4 Kawasaki Frontale
| 05.09.2021 | Kawasaki Frontale | 3-3 | Urawa Red Diamonds | |
| 01.09.2021 | Urawa Red Diamonds | 1-1 | Kawasaki Frontale | |