*Atlante FC 5-3 Celaya FC
| 01.05.2021 | Celaya FC | 3-3 | Atlante FC | |
| 27.04.2021 | Atlante FC | 2-0 | Celaya FC | |
*Tepatitlan FC 6-1 Cimarrones Sonora
| 02.05.2021 | Cimarrones Sonora | 1-4 | Tepatitlan FC | |
| 29.04.2021 | Tepatitlan FC | 2-0 | Cimarrones Sonora | |
CD Tapatio 1-3 Mineros de Zacatecas *
| 03.05.2021 | Mineros de Zacatecas | 2-1 | CD Tapatio | |
| 30.04.2021 | CD Tapatio | 0-1 | Mineros de Zacatecas | |