Leones Negros 1-3 Celaya FC *
| 06.12.2021 | Celaya FC | 3-0 | Leones Negros | |
| 01.12.2021 | Leones Negros | 1-0 | Celaya FC | |
*Tampico Madero 4-2 Atlético Morelia
| 05.12.2021 | Atlético Morelia | 0-2 | Tampico Madero | |
| 01.12.2021 | Tampico Madero | 2-2 | Atlético Morelia | |
Tepatitlán FC 0-2 Dorados Sinaloa *
| 05.12.2021 | Dorados Sinaloa | 1-0 | Tepatitlán FC | |
| 02.12.2021 | Tepatitlán FC | 0-1 | Dorados Sinaloa | |
Venados Yucatán 0-2 Atlante FC *
| 05.12.2021 | Atlante FC | 0-0 | Venados Yucatán | |
| 03.12.2021 | Venados Yucatán | 0-2 | Atlante FC | |