Deportivo Toluca 4-5 Club América *
| 03.12.2018 | Club América | 3-2 | Deportivo Toluca | |
| 30.11.2018 | Deportivo Toluca | 2-2 | Club América | |
Querétaro FC 1-3 Cruz Azul *
| 02.12.2018 | Cruz Azul | 1-1 | Querétaro FC | |
| 29.11.2018 | Querétaro FC | 0-2 | Cruz Azul | |
*CF Monterrey 3-0 Santos Laguna
| 02.12.2018 | Santos Laguna | 0-2 | CF Monterrey | |
| 29.11.2018 | CF Monterrey | 1-0 | Santos Laguna | |
Tigres UANL 3-4 UNAM Pumas *
| 02.12.2018 | UNAM Pumas | 3-1 | Tigres UANL | |
| 30.11.2018 | Tigres UANL | 2-1 | UNAM Pumas | |